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Isolation and Assessment of the in Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea
The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A (3) and B (4), hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cyto...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306946/ https://www.ncbi.nlm.nih.gov/pubmed/25603342 http://dx.doi.org/10.3390/md13010444 |
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| author | Esposito, Germana Teta, Roberta Miceli, Roberta Ceccarelli, Luca S. Della Sala, Gerardo Camerlingo, Rosa Irollo, Elena Mangoni, Alfonso Pirozzi, Giuseppe Costantino, Valeria |
| author_facet | Esposito, Germana Teta, Roberta Miceli, Roberta Ceccarelli, Luca S. Della Sala, Gerardo Camerlingo, Rosa Irollo, Elena Mangoni, Alfonso Pirozzi, Giuseppe Costantino, Valeria |
| author_sort | Esposito, Germana |
| collection | PubMed |
| description | The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A (3) and B (4), hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cytotoxic activity at nanomolar levels, with selectivity over ovarian cancer cells and a pro-apoptotic mechanism. |
| format | Online Article Text |
| id | pubmed-4306946 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-43069462015-02-02 Isolation and Assessment of the in Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea Esposito, Germana Teta, Roberta Miceli, Roberta Ceccarelli, Luca S. Della Sala, Gerardo Camerlingo, Rosa Irollo, Elena Mangoni, Alfonso Pirozzi, Giuseppe Costantino, Valeria Mar Drugs Article The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A (3) and B (4), hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cytotoxic activity at nanomolar levels, with selectivity over ovarian cancer cells and a pro-apoptotic mechanism. MDPI 2015-01-16 /pmc/articles/PMC4306946/ /pubmed/25603342 http://dx.doi.org/10.3390/md13010444 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Esposito, Germana Teta, Roberta Miceli, Roberta Ceccarelli, Luca S. Della Sala, Gerardo Camerlingo, Rosa Irollo, Elena Mangoni, Alfonso Pirozzi, Giuseppe Costantino, Valeria Isolation and Assessment of the in Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea |
| title | Isolation and Assessment of the in Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea |
| title_full | Isolation and Assessment of the in Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea |
| title_fullStr | Isolation and Assessment of the in Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea |
| title_full_unstemmed | Isolation and Assessment of the in Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea |
| title_short | Isolation and Assessment of the in Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea |
| title_sort | isolation and assessment of the in vitro anti-tumor activity of smenothiazole a and b, chlorinated thiazole-containing peptide/polyketides from the caribbean sponge, smenospongia aurea |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306946/ https://www.ncbi.nlm.nih.gov/pubmed/25603342 http://dx.doi.org/10.3390/md13010444 |
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