Cargando…

Activation of p53 with Ilimaquinone and Ethylsmenoquinone, Marine Sponge Metabolites, Induces Apoptosis and Autophagy in Colon Cancer Cells

The tumor suppressor, p53, plays an essential role in the cellular response to stress through regulating the expression of genes involved in cell cycle arrest, apoptosis and autophagy. Here, we used a cell-based reporter system for the detection of p53 response transcription to identify the marine s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Hyun-Young, Chung, Kyu Jin, Hwang, In Hyun, Gwak, Jungsuk, Park, Seoyoung, Ju, Bong Gun, Yun, Eunju, Kim, Dong-Eun, Chung, Young-Hwa, Na, MinKyun, Song, Gyu-Yong, Oh, Sangtaek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306951/ https://www.ncbi.nlm.nih.gov/pubmed/25603347 http://dx.doi.org/10.3390/md13010543

Ejemplares similares

Ilimaquinone and Ethylsmenoquinone, Marine Sponge Metabolites, Suppress the Proliferation of Multiple Myeloma Cells by Down-Regulating the Level of β-Catenin
por: Park, Seoyoung, et al.
Publicado: (2014)

Stereo-Selective Pharmacokinetics of Ilimaquinone Epimers Extracted from a Marine Sponge in Rats
por: Son, Heebin, et al.
Publicado: (2019)

Ilimaquinone (Marine Sponge Metabolite) Induces Apoptosis in HCT-116 Human Colorectal Carcinoma Cells via Mitochondrial-Mediated Apoptosis Pathway
por: Surti, Malvi, et al.
Publicado: (2022)

Pro-Apoptotic Activity of the Marine Sponge Dactylospongia elegans Metabolites Pelorol and 5-epi-Ilimaquinone on Human 501Mel Melanoma Cells
por: Carpi, Sara, et al.
Publicado: (2022)

Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells
por: Park, Hyun Bong, et al.
Publicado: (2018)

Small Molecule-Based Promotion of PKCα-Mediated β-Catenin Degradation Suppresses the Proliferation of CRT-Positive Cancer Cells
por: Gwak, Jungsug, et al.
Publicado: (2012)

Cytotoxic Activity of Rearranged Drimane Meroterpenoids against Colon Cancer Cells via Down-Regulation of β-Catenin Expression
por: Hwang, In Hyun, et al.
Publicado: (2015)

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
por: Surti, Malvi, et al.
Publicado: (2020)

Wnt5a attenuates the pathogenic effects of the Wnt/β-catenin pathway in human retinal pigment epithelial cells via down-regulating β-catenin and Snail
por: Kim, Joo-Hyun, et al.
Publicado: (2015)

Cytotoxic Activity of Aplykurodin A Isolated From Aplysia kurodai against AXIN1-Mutated Hepatocellular Carcinoma Cells by Promoting Oncogenic β-Catenin Degradation
por: Lee, Jaehoo, et al.
Publicado: (2020)

Anticancer Effects of the Marine Sponge Lipastrotethya sp. Extract on Wild-Type and p53 Knockout HCT116 Cells
por: Choi, Kiheon, et al.
Publicado: (2017)

Ilimaquinone Induces the Apoptotic Cell Death of Cancer Cells by Reducing Pyruvate Dehydrogenase Kinase 1 Activity
por: Kwak, Choong-Hwan, et al.
Publicado: (2020)

Ilimaquinone Induces Apoptosis and Autophagy in Human Oral Squamous Cell Carcinoma Cells
por: Lin, Cheng-Wen, et al.
Publicado: (2020)

CCAAT/enhancer-binding protein-β functions as a negative regulator of Wnt/β-catenin signaling through activation of AXIN1 gene expression
por: Park, Seoyoung, et al.
Publicado: (2018)

Anticancer Activity of Marine Sponge Hyrtios sp. Extract in Human Colorectal Carcinoma RKO Cells with Different p53 Status
por: Lim, Hyun Kyung, et al.
Publicado: (2014)

Pectenotoxin-2 from Marine Sponges: A Potential Anti-Cancer Agent—A Review
por: Kim, Gi-Young, et al.
Publicado: (2011)

Secondary Metabolites from the Marine Sponge Genus Phyllospongia
por: Zhang, Huawei, et al.
Publicado: (2017)

General Methodologies Toward cis-Fused Quinone Sesquiterpenoids. Enantiospecific Synthesis of the epi-Ilimaquinone Core Featuring Sc-Catalyzed Ring Expansion
por: Kaplan, Hilan Z., et al.
Publicado: (2017)

The Chemistry of Marine Sponges(∗)
por: Ebada, Sherif S., et al.
Publicado: (2012)

Marine Sponges as Pharmacy
por: Sipkema, Detmer, et al.
Publicado: (2005)

SFMBT2 (Scm-like with four mbt domains 2) negatively regulates cell migration and invasion in prostate cancer cells
por: Gwak, Jungsug, et al.
Publicado: (2016)

Bioactive Secondary Metabolites from the Marine Sponge Genus Agelas
por: Zhang, Huawei, et al.
Publicado: (2017)

Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.
por: Lee, Yoonyeong, et al.
Publicado: (2012)

Adrenocorticotropic Hormone-Secreting Esthesioneuroblastoma with Ectopic Cushing's Syndrome
por: Chung, Young Soo, et al.
Publicado: (2020)

Bioactive Nitrogenous Secondary Metabolites from the Marine Sponge Genus Haliclona
por: Zhu, Jiaying, et al.
Publicado: (2019)

Increasing Metabolic Diversity in Marine Sponges Extracts by Controlling Extraction Parameters
por: Bayona, Lina M., et al.
Publicado: (2018)

Antifungal Activity of (+)-Curcuphenol, a Metabolite from the Marine Sponge Didiscus oxeata
por: Gaspar, Helena, et al.
Publicado: (2004)

New Isomalabaricane-Derived Metabolites from a Stelletta sp. Marine Sponge
por: Kolesnikova, Sophia A., et al.
Publicado: (2021)

Secondary Metabolites from Marine Sponges of the Genus Oceanapia: Chemistry and Biological Activities
por: Xu, Meng-Juan, et al.
Publicado: (2022)

New Metabolites from the Marine Sponge Scopalina hapalia Collected in Mayotte Lagoon
por: Saïd Hassane, Charifat, et al.
Publicado: (2022)

The Effects of Sampling and Storage Conditions on the Metabolite Profile of the Marine Sponge Geodia barretti
por: Erngren, Ida, et al.
Publicado: (2021)

Kinase Inhibitors from Marine Sponges
por: Skropeta, Danielle, et al.
Publicado: (2011)

Marine Sponges as a Drug Treasure
por: Anjum, Komal, et al.
Publicado: (2016)

Terpene biosynthesis in marine sponge animals
por: Wilson, Kayla, et al.
Publicado: (2023)

Adenocarcinoma Arising in a Colonic Duplication Cyst: A Case Report and Review of the Literature
por: Kang, Myunghee, et al.
Publicado: (2014)

Sponge diversification in marine lakes: Implications for phylogeography and population genomic studies on sponges
por: Maas, Diede L., et al.
Publicado: (2023)

Bioactive Secondary Metabolites from the Red Sea Marine Verongid Sponge Suberea Species
por: Shaala, Lamiaa A., et al.
Publicado: (2015)

Synthesis and Bioactivity of Secondary Metabolites from Marine Sponges Containing Dibrominated Indolic Systems
por: Mollica, Adriano, et al.
Publicado: (2012)

The Chemically Highly Diversified Metabolites from the Red Sea Marine Sponge Spongia sp.
por: Tai, Chi-Jen, et al.
Publicado: (2022)

Metabolites and Bioactivity of the Marine Xestospongia Sponges (Porifera, Demospongiae, Haplosclerida) of Southeast Asian Waters
por: Khodzori, Fikri Akmal, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_19q2ghb5l73o4iljophpv4pggh