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Design, Synthesis and Evaluation of New Marine Alkaloid-Derived Pentacyclic Structures with Anti-Tumoral Potency

This work describes the synthesis and biological evaluation of a new heterocyclic hybrid derived from the ellipticine and the marine alkaloid makaluvamine A. Pyridoquinoxalinedione 12 was obtained in seven steps with 6.5% overall yield. 12 and its intermediates 1–11 were evaluated for their in vitro...

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Detalles Bibliográficos
Autores principales:	Boucle, Sebastien, Melin, Celine, Clastre, Marc, Guillard, Jerome
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306956/ https://www.ncbi.nlm.nih.gov/pubmed/25607930 http://dx.doi.org/10.3390/md13010655

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