Effect of vaginal misoprostol on pregnancy rate after intrauterine insemination: a randomized controlled trial

BACKGROUND: Intrauterine insemination (IUI) is one of the most appropriate and cost-effective methods in infertility treatment. OBJECTIVE: We aimed to investigate effect of vaginal misoprostol on pregnancy rate after IUI. MATERIALS AND METHODS: Two hundred and ten infertile women who were referred to Infertility Clinic of Alzahra Hospital by an indication of IUI during 2012-2013 were randomly assigned to receive 200 µg vaginal misoprostol (n=105) or vaginal placebo (n=105) after IUI. For detecting pregnancy, past 2 weeks, beta human chorionic gonadotropin evaluation was made and if positive, transvaginal sonography was done for evaluation of pregnancy 2-3 weeks later and clinical pregnancy was recorded. RESULTS: Pregnancy had been noted in 24 patients in misoprotol (22.9%) and 27 patients in placebo (25.7%) groups that this difference was not significant (p=0.748). In misoprostol group, 3 case of nausea and vomiting (2.9%) had been observed. CONCLUSION: According to the results, administering 200 µg vaginal misoprostol after IUI doesn’t have significant effect on the success rate of IUI.