Prediction of signaling cross-talks contributing to acquired drug resistance in breast cancer cells by Bayesian statistical modeling

BACKGROUND: Initial success of inhibitors targeting oncogenes is often followed by tumor relapse due to acquired resistance. In addition to mutations in targeted oncogenes, signaling cross-talks among pathways play a vital role in such drug inefficacy. These include activation of compensatory pathwa...

Descripción completa

Detalles Bibliográficos
Autores principales: Azad, AKM, Lawen, Alfons, Keith, Jonathan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307189/
https://www.ncbi.nlm.nih.gov/pubmed/25599599
http://dx.doi.org/10.1186/s12918-014-0135-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307189/
https://www.ncbi.nlm.nih.gov/pubmed/25599599
http://dx.doi.org/10.1186/s12918-014-0135-x

Ejemplares similares