Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung

BACKGROUND: Earlier studies have reported that transforming growth factor beta 1(TGFβ1) is a critical mediator of hyperoxia-induced acute lung injury (HALI) in developing lungs, leading to impaired alveolarization and a pulmonary phenotype of bronchopulmonary dysplasia (BPD). However, the mechanisms...

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Detalles Bibliográficos
Autores principales: Sureshbabu, Angara, Syed, Mansoor A, Boddupalli, Chandra Sekhar, Dhodapkar, Madhav V, Homer, Robert J, Minoo, Parviz, Bhandari, Vineet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307226/
https://www.ncbi.nlm.nih.gov/pubmed/25591994
http://dx.doi.org/10.1186/s12931-014-0162-6

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