Cargando…

Formins: Linking Cytoskeleton and Endomembranes in Plant Cells

The cytoskeleton plays a central part in spatial organization of the plant cytoplasm, including the endomebrane system. However, the mechanisms involved are so far only partially understood. Formins (FH2 proteins), a family of evolutionarily conserved proteins sharing the FH2 domain whose dimer can...

Descripción completa

Detalles Bibliográficos
Autores principales: Cvrčková, Fatima, Oulehlová, Denisa, Žárský, Viktor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307232/
https://www.ncbi.nlm.nih.gov/pubmed/25546384
http://dx.doi.org/10.3390/ijms16010001
_version_ 1782354425709330432
author Cvrčková, Fatima
Oulehlová, Denisa
Žárský, Viktor
author_facet Cvrčková, Fatima
Oulehlová, Denisa
Žárský, Viktor
author_sort Cvrčková, Fatima
collection PubMed
description The cytoskeleton plays a central part in spatial organization of the plant cytoplasm, including the endomebrane system. However, the mechanisms involved are so far only partially understood. Formins (FH2 proteins), a family of evolutionarily conserved proteins sharing the FH2 domain whose dimer can nucleate actin, mediate the co-ordination between actin and microtubule cytoskeletons in multiple eukaryotic lineages including plants. Moreover, some plant formins contain transmembrane domains and participate in anchoring cytoskeletal structures to the plasmalemma, and possibly to other membranes. Direct or indirect membrane association is well documented even for some fungal and metazoan formins lacking membrane insertion motifs, and FH2 proteins have been shown to associate with endomembranes and modulate their dynamics in both fungi and metazoans. Here we summarize the available evidence suggesting that formins participate in membrane trafficking and endomembrane, especially ER, organization also in plants. We propose that, despite some methodological pitfalls inherent to in vivo studies based on (over)expression of truncated and/or tagged proteins, formins are beginning to emerge as candidates for the so far somewhat elusive link between the plant cytoskeleton and the endomembrane system.
format Online
Article
Text
id pubmed-4307232
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-43072322015-02-02 Formins: Linking Cytoskeleton and Endomembranes in Plant Cells Cvrčková, Fatima Oulehlová, Denisa Žárský, Viktor Int J Mol Sci Review The cytoskeleton plays a central part in spatial organization of the plant cytoplasm, including the endomebrane system. However, the mechanisms involved are so far only partially understood. Formins (FH2 proteins), a family of evolutionarily conserved proteins sharing the FH2 domain whose dimer can nucleate actin, mediate the co-ordination between actin and microtubule cytoskeletons in multiple eukaryotic lineages including plants. Moreover, some plant formins contain transmembrane domains and participate in anchoring cytoskeletal structures to the plasmalemma, and possibly to other membranes. Direct or indirect membrane association is well documented even for some fungal and metazoan formins lacking membrane insertion motifs, and FH2 proteins have been shown to associate with endomembranes and modulate their dynamics in both fungi and metazoans. Here we summarize the available evidence suggesting that formins participate in membrane trafficking and endomembrane, especially ER, organization also in plants. We propose that, despite some methodological pitfalls inherent to in vivo studies based on (over)expression of truncated and/or tagged proteins, formins are beginning to emerge as candidates for the so far somewhat elusive link between the plant cytoskeleton and the endomembrane system. MDPI 2014-12-23 /pmc/articles/PMC4307232/ /pubmed/25546384 http://dx.doi.org/10.3390/ijms16010001 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cvrčková, Fatima
Oulehlová, Denisa
Žárský, Viktor
Formins: Linking Cytoskeleton and Endomembranes in Plant Cells
title Formins: Linking Cytoskeleton and Endomembranes in Plant Cells
title_full Formins: Linking Cytoskeleton and Endomembranes in Plant Cells
title_fullStr Formins: Linking Cytoskeleton and Endomembranes in Plant Cells
title_full_unstemmed Formins: Linking Cytoskeleton and Endomembranes in Plant Cells
title_short Formins: Linking Cytoskeleton and Endomembranes in Plant Cells
title_sort formins: linking cytoskeleton and endomembranes in plant cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307232/
https://www.ncbi.nlm.nih.gov/pubmed/25546384
http://dx.doi.org/10.3390/ijms16010001
work_keys_str_mv AT cvrckovafatima forminslinkingcytoskeletonandendomembranesinplantcells
AT oulehlovadenisa forminslinkingcytoskeletonandendomembranesinplantcells
AT zarskyviktor forminslinkingcytoskeletonandendomembranesinplantcells