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Formins: Linking Cytoskeleton and Endomembranes in Plant Cells
The cytoskeleton plays a central part in spatial organization of the plant cytoplasm, including the endomebrane system. However, the mechanisms involved are so far only partially understood. Formins (FH2 proteins), a family of evolutionarily conserved proteins sharing the FH2 domain whose dimer can...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307232/ https://www.ncbi.nlm.nih.gov/pubmed/25546384 http://dx.doi.org/10.3390/ijms16010001 |
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author | Cvrčková, Fatima Oulehlová, Denisa Žárský, Viktor |
author_facet | Cvrčková, Fatima Oulehlová, Denisa Žárský, Viktor |
author_sort | Cvrčková, Fatima |
collection | PubMed |
description | The cytoskeleton plays a central part in spatial organization of the plant cytoplasm, including the endomebrane system. However, the mechanisms involved are so far only partially understood. Formins (FH2 proteins), a family of evolutionarily conserved proteins sharing the FH2 domain whose dimer can nucleate actin, mediate the co-ordination between actin and microtubule cytoskeletons in multiple eukaryotic lineages including plants. Moreover, some plant formins contain transmembrane domains and participate in anchoring cytoskeletal structures to the plasmalemma, and possibly to other membranes. Direct or indirect membrane association is well documented even for some fungal and metazoan formins lacking membrane insertion motifs, and FH2 proteins have been shown to associate with endomembranes and modulate their dynamics in both fungi and metazoans. Here we summarize the available evidence suggesting that formins participate in membrane trafficking and endomembrane, especially ER, organization also in plants. We propose that, despite some methodological pitfalls inherent to in vivo studies based on (over)expression of truncated and/or tagged proteins, formins are beginning to emerge as candidates for the so far somewhat elusive link between the plant cytoskeleton and the endomembrane system. |
format | Online Article Text |
id | pubmed-4307232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-43072322015-02-02 Formins: Linking Cytoskeleton and Endomembranes in Plant Cells Cvrčková, Fatima Oulehlová, Denisa Žárský, Viktor Int J Mol Sci Review The cytoskeleton plays a central part in spatial organization of the plant cytoplasm, including the endomebrane system. However, the mechanisms involved are so far only partially understood. Formins (FH2 proteins), a family of evolutionarily conserved proteins sharing the FH2 domain whose dimer can nucleate actin, mediate the co-ordination between actin and microtubule cytoskeletons in multiple eukaryotic lineages including plants. Moreover, some plant formins contain transmembrane domains and participate in anchoring cytoskeletal structures to the plasmalemma, and possibly to other membranes. Direct or indirect membrane association is well documented even for some fungal and metazoan formins lacking membrane insertion motifs, and FH2 proteins have been shown to associate with endomembranes and modulate their dynamics in both fungi and metazoans. Here we summarize the available evidence suggesting that formins participate in membrane trafficking and endomembrane, especially ER, organization also in plants. We propose that, despite some methodological pitfalls inherent to in vivo studies based on (over)expression of truncated and/or tagged proteins, formins are beginning to emerge as candidates for the so far somewhat elusive link between the plant cytoskeleton and the endomembrane system. MDPI 2014-12-23 /pmc/articles/PMC4307232/ /pubmed/25546384 http://dx.doi.org/10.3390/ijms16010001 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cvrčková, Fatima Oulehlová, Denisa Žárský, Viktor Formins: Linking Cytoskeleton and Endomembranes in Plant Cells |
title | Formins: Linking Cytoskeleton and Endomembranes in Plant Cells |
title_full | Formins: Linking Cytoskeleton and Endomembranes in Plant Cells |
title_fullStr | Formins: Linking Cytoskeleton and Endomembranes in Plant Cells |
title_full_unstemmed | Formins: Linking Cytoskeleton and Endomembranes in Plant Cells |
title_short | Formins: Linking Cytoskeleton and Endomembranes in Plant Cells |
title_sort | formins: linking cytoskeleton and endomembranes in plant cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307232/ https://www.ncbi.nlm.nih.gov/pubmed/25546384 http://dx.doi.org/10.3390/ijms16010001 |
work_keys_str_mv | AT cvrckovafatima forminslinkingcytoskeletonandendomembranesinplantcells AT oulehlovadenisa forminslinkingcytoskeletonandendomembranesinplantcells AT zarskyviktor forminslinkingcytoskeletonandendomembranesinplantcells |