Cargando…
Oxidative Stress and Its Significant Roles in Neurodegenerative Diseases and Cancer
Reactive oxygen and nitrogen species have been implicated in diverse pathophysiological conditions, including inflammation, neurodegenerative diseases and cancer. Accumulating evidence indicates that oxidative damage to biomolecules including lipids, proteins and DNA, contributes to these diseases....
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307243/ https://www.ncbi.nlm.nih.gov/pubmed/25547488 http://dx.doi.org/10.3390/ijms16010193 |
_version_ | 1782354428341256192 |
---|---|
author | Thanan, Raynoo Oikawa, Shinji Hiraku, Yusuke Ohnishi, Shiho Ma, Ning Pinlaor, Somchai Yongvanit, Puangrat Kawanishi, Shosuke Murata, Mariko |
author_facet | Thanan, Raynoo Oikawa, Shinji Hiraku, Yusuke Ohnishi, Shiho Ma, Ning Pinlaor, Somchai Yongvanit, Puangrat Kawanishi, Shosuke Murata, Mariko |
author_sort | Thanan, Raynoo |
collection | PubMed |
description | Reactive oxygen and nitrogen species have been implicated in diverse pathophysiological conditions, including inflammation, neurodegenerative diseases and cancer. Accumulating evidence indicates that oxidative damage to biomolecules including lipids, proteins and DNA, contributes to these diseases. Previous studies suggest roles of lipid peroxidation and oxysterols in the development of neurodegenerative diseases and inflammation-related cancer. Our recent studies identifying and characterizing carbonylated proteins reveal oxidative damage to heat shock proteins in neurodegenerative disease models and inflammation-related cancer, suggesting dysfunction in their antioxidative properties. In neurodegenerative diseases, DNA damage may not only play a role in the induction of apoptosis, but also may inhibit cellular division via telomere shortening. Immunohistochemical analyses showed co-localization of oxidative/nitrative DNA lesions and stemness markers in the cells of inflammation-related cancers. Here, we review oxidative stress and its significant roles in neurodegenerative diseases and cancer. |
format | Online Article Text |
id | pubmed-4307243 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-43072432015-02-02 Oxidative Stress and Its Significant Roles in Neurodegenerative Diseases and Cancer Thanan, Raynoo Oikawa, Shinji Hiraku, Yusuke Ohnishi, Shiho Ma, Ning Pinlaor, Somchai Yongvanit, Puangrat Kawanishi, Shosuke Murata, Mariko Int J Mol Sci Review Reactive oxygen and nitrogen species have been implicated in diverse pathophysiological conditions, including inflammation, neurodegenerative diseases and cancer. Accumulating evidence indicates that oxidative damage to biomolecules including lipids, proteins and DNA, contributes to these diseases. Previous studies suggest roles of lipid peroxidation and oxysterols in the development of neurodegenerative diseases and inflammation-related cancer. Our recent studies identifying and characterizing carbonylated proteins reveal oxidative damage to heat shock proteins in neurodegenerative disease models and inflammation-related cancer, suggesting dysfunction in their antioxidative properties. In neurodegenerative diseases, DNA damage may not only play a role in the induction of apoptosis, but also may inhibit cellular division via telomere shortening. Immunohistochemical analyses showed co-localization of oxidative/nitrative DNA lesions and stemness markers in the cells of inflammation-related cancers. Here, we review oxidative stress and its significant roles in neurodegenerative diseases and cancer. MDPI 2014-12-24 /pmc/articles/PMC4307243/ /pubmed/25547488 http://dx.doi.org/10.3390/ijms16010193 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Thanan, Raynoo Oikawa, Shinji Hiraku, Yusuke Ohnishi, Shiho Ma, Ning Pinlaor, Somchai Yongvanit, Puangrat Kawanishi, Shosuke Murata, Mariko Oxidative Stress and Its Significant Roles in Neurodegenerative Diseases and Cancer |
title | Oxidative Stress and Its Significant Roles in Neurodegenerative Diseases and Cancer |
title_full | Oxidative Stress and Its Significant Roles in Neurodegenerative Diseases and Cancer |
title_fullStr | Oxidative Stress and Its Significant Roles in Neurodegenerative Diseases and Cancer |
title_full_unstemmed | Oxidative Stress and Its Significant Roles in Neurodegenerative Diseases and Cancer |
title_short | Oxidative Stress and Its Significant Roles in Neurodegenerative Diseases and Cancer |
title_sort | oxidative stress and its significant roles in neurodegenerative diseases and cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307243/ https://www.ncbi.nlm.nih.gov/pubmed/25547488 http://dx.doi.org/10.3390/ijms16010193 |
work_keys_str_mv | AT thananraynoo oxidativestressanditssignificantrolesinneurodegenerativediseasesandcancer AT oikawashinji oxidativestressanditssignificantrolesinneurodegenerativediseasesandcancer AT hirakuyusuke oxidativestressanditssignificantrolesinneurodegenerativediseasesandcancer AT ohnishishiho oxidativestressanditssignificantrolesinneurodegenerativediseasesandcancer AT maning oxidativestressanditssignificantrolesinneurodegenerativediseasesandcancer AT pinlaorsomchai oxidativestressanditssignificantrolesinneurodegenerativediseasesandcancer AT yongvanitpuangrat oxidativestressanditssignificantrolesinneurodegenerativediseasesandcancer AT kawanishishosuke oxidativestressanditssignificantrolesinneurodegenerativediseasesandcancer AT muratamariko oxidativestressanditssignificantrolesinneurodegenerativediseasesandcancer |