The Anticancer Drug Ellipticine Activated with Cytochrome P450 Mediates DNA Damage Determining Its Pharmacological Efficiencies: Studies with Rats, Hepatic Cytochrome P450 Reductase Null (HRN™) Mice and Pure Enzymes

Ellipticine is a DNA-damaging agent acting as a prodrug whose pharmacological efficiencies and genotoxic side effects are dictated by activation with cytochrome P450 (CYP). Over the last decade we have gained extensive experience in using pure enzymes and various animal models that helped to identif...

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Detalles Bibliográficos
Autores principales: Stiborová, Marie, Černá, Věra, Moserová, Michaela, Mrízová, Iveta, Arlt, Volker M., Frei, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307247/
https://www.ncbi.nlm.nih.gov/pubmed/25547492
http://dx.doi.org/10.3390/ijms16010284

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