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Accelerating in Situ Endothelialisation of Cardiovascular Bypass Grafts

The patency of synthetic cardiovascular grafts in the long run is synonymous with their ability to inhibit the processes of intimal hyperplasia, thrombosis and calcification. In the human body, the endothelium of blood vessels exhibits characteristics that inhibit such processes. As such it is not s...

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Autores principales: Goh, Ee Teng, Wong, Eleanor, Farhatnia, Yasmin, Tan, Aaron, Seifalian, Alexander M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307264/
https://www.ncbi.nlm.nih.gov/pubmed/25551605
http://dx.doi.org/10.3390/ijms16010597
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author Goh, Ee Teng
Wong, Eleanor
Farhatnia, Yasmin
Tan, Aaron
Seifalian, Alexander M.
author_facet Goh, Ee Teng
Wong, Eleanor
Farhatnia, Yasmin
Tan, Aaron
Seifalian, Alexander M.
author_sort Goh, Ee Teng
collection PubMed
description The patency of synthetic cardiovascular grafts in the long run is synonymous with their ability to inhibit the processes of intimal hyperplasia, thrombosis and calcification. In the human body, the endothelium of blood vessels exhibits characteristics that inhibit such processes. As such it is not surprising that research in tissue engineering is directed towards replicating the functionality of the natural endothelium in cardiovascular grafts. This can be done either by seeding the endothelium within the lumen of the grafts prior to implantation or by designing the graft such that in situ endothelialisation takes place after implantation. Due to certain difficulties identified with in vitro endothelialisation, in situ endothelialisation, which will be the focus of this article, has garnered interest in the last years. To promote in situ endothelialisation, the following aspects can be taken into account: (1) Endothelial progenital cell mobilization, adhesion and proliferation; (2) Regulating differentiation of progenitor cells to mature endothelium; (3) Preventing thrombogenesis and inflammation during endothelialisation. This article aims to review and compile recent developments to promote the in situ endothelialisation of cardiovascular grafts and subsequently improve their patency, which can also have widespread implications in the field of tissue engineering.
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spelling pubmed-43072642015-02-02 Accelerating in Situ Endothelialisation of Cardiovascular Bypass Grafts Goh, Ee Teng Wong, Eleanor Farhatnia, Yasmin Tan, Aaron Seifalian, Alexander M. Int J Mol Sci Review The patency of synthetic cardiovascular grafts in the long run is synonymous with their ability to inhibit the processes of intimal hyperplasia, thrombosis and calcification. In the human body, the endothelium of blood vessels exhibits characteristics that inhibit such processes. As such it is not surprising that research in tissue engineering is directed towards replicating the functionality of the natural endothelium in cardiovascular grafts. This can be done either by seeding the endothelium within the lumen of the grafts prior to implantation or by designing the graft such that in situ endothelialisation takes place after implantation. Due to certain difficulties identified with in vitro endothelialisation, in situ endothelialisation, which will be the focus of this article, has garnered interest in the last years. To promote in situ endothelialisation, the following aspects can be taken into account: (1) Endothelial progenital cell mobilization, adhesion and proliferation; (2) Regulating differentiation of progenitor cells to mature endothelium; (3) Preventing thrombogenesis and inflammation during endothelialisation. This article aims to review and compile recent developments to promote the in situ endothelialisation of cardiovascular grafts and subsequently improve their patency, which can also have widespread implications in the field of tissue engineering. MDPI 2014-12-29 /pmc/articles/PMC4307264/ /pubmed/25551605 http://dx.doi.org/10.3390/ijms16010597 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Goh, Ee Teng
Wong, Eleanor
Farhatnia, Yasmin
Tan, Aaron
Seifalian, Alexander M.
Accelerating in Situ Endothelialisation of Cardiovascular Bypass Grafts
title Accelerating in Situ Endothelialisation of Cardiovascular Bypass Grafts
title_full Accelerating in Situ Endothelialisation of Cardiovascular Bypass Grafts
title_fullStr Accelerating in Situ Endothelialisation of Cardiovascular Bypass Grafts
title_full_unstemmed Accelerating in Situ Endothelialisation of Cardiovascular Bypass Grafts
title_short Accelerating in Situ Endothelialisation of Cardiovascular Bypass Grafts
title_sort accelerating in situ endothelialisation of cardiovascular bypass grafts
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307264/
https://www.ncbi.nlm.nih.gov/pubmed/25551605
http://dx.doi.org/10.3390/ijms16010597
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