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Trans-Splicing Improvement by the Combined Application of Antisense Strategies

Spliceosome-mediated RNA trans-splicing has become an emergent tool for the repair of mutated pre-mRNAs in the treatment of genetic diseases. RNA trans-splicing molecules (RTMs) are designed to induce a specific trans-splicing reaction via a binding domain for a respective target pre-mRNA region. A...

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Detalles Bibliográficos
Autores principales:	Koller, Ulrich, Hainzl, Stefan, Kocher, Thomas, Hüttner, Clemens, Klausegger, Alfred, Gruber, Christina, Mayr, Elisabeth, Wally, Verena, Bauer, Johann W., Murauer, Eva M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307297/ https://www.ncbi.nlm.nih.gov/pubmed/25569093 http://dx.doi.org/10.3390/ijms16011179

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