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Molecular Targeting of the Oncoprotein PLK1 in Pediatric Acute Myeloid Leukemia: RO3280, a Novel PLK1 Inhibitor, Induces Apoptosis in Leukemia Cells
Polo-like kinase 1 (PLK1) is highly expressed in many cancers and therefore a biomarker of transformation and potential target for the development of cancer-specific small molecule drugs. RO3280 was recently identified as a novel PLK1 inhibitor; however its therapeutic effects in leukemia treatment...
Autores principales: | Wang, Na-Na, Li, Zhi-Heng, Zhao, He, Tao, Yan-Fang, Xu, Li-Xiao, Lu, Jun, Cao, Lan, Du, Xiao-Juan, Sun, Li-Chao, Zhao, Wen-Li, Xiao, Pei-Fang, Fang, Fang, Su, Guang-Hao, Li, Yan-Hong, Li, Gang, Li, Yi-Ping, Xu, Yun-Yun, Zhou, Hui-Ting, Wu, Yi, Jin, Mei-Fang, Liu, Lin, Ni, Jian, Wang, Jian, Hu, Shao-Yan, Zhu, Xue-Ming, Feng, Xing, Pan, Jian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307303/ https://www.ncbi.nlm.nih.gov/pubmed/25574601 http://dx.doi.org/10.3390/ijms16011266 |
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