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Pars Plana Vitrectomy and Silicone Oil Injection in Phakic and Pseudophakic Eyes; Corneal Endothelial Changes

PURPOSE: To evaluate the effect of silicone oil (SO) on the corneal endothelium in SO filled phakic and pseudophakic vitrectomizied eyes. METHODS: This prospective comparative consecutive case-control study evaluated the corneal endothelial characteristics of 64 SO filled vitrectomizied eyes (case g...

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Autores principales: Farrahi, Fereydoun, Feghhi, Mostafa, Ostadian, Farshad, Alivand, Arash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307659/
https://www.ncbi.nlm.nih.gov/pubmed/25667730
http://dx.doi.org/10.4103/2008-322X.143361
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author Farrahi, Fereydoun
Feghhi, Mostafa
Ostadian, Farshad
Alivand, Arash
author_facet Farrahi, Fereydoun
Feghhi, Mostafa
Ostadian, Farshad
Alivand, Arash
author_sort Farrahi, Fereydoun
collection PubMed
description PURPOSE: To evaluate the effect of silicone oil (SO) on the corneal endothelium in SO filled phakic and pseudophakic vitrectomizied eyes. METHODS: This prospective comparative consecutive case-control study evaluated the corneal endothelial characteristics of 64 SO filled vitrectomizied eyes (case group) as compared to 46 vitrectomizied eyes without SO injection (control group). Endothelial cell densities (ECD), coefficient of variation (CV), and percentage of hexagonal cells (hexagonality) at the corneal center were evaluated preoperatively, 1 month and 6 months after surgery using noncontact specular microscopy and were compared between the two groups. Exclusion criteria were previous vitreoretinal surgery, aphakia, any degree of anterior chamber inflammation, SO bubbles in the anterior chamber and increased intraocular pressure in the postoperative period. RESULTS: Six months after SO injection, mean ECD was 2,438.2±327.6 cell/mm(2) in the case group and 2,462.6±361.7 cell/mm(2) in the control group (P = 0.714) and mean hexagonality was 49.6 ± 6.8 and 54.6 ± 8.9, in the case and control groups, respectively (P = 0.004). Six months after operation, CV in the case group was 39.3 ± 5.6 and that in the control group was 35.7 ± 6.4 (P = 0.003). CONCLUSION: Although the presence of SO in the vitreous cavity of phakic and pseudophakic eyes causes slight reduction in the number of endothelial cells, however it leads to significant changes in endothelial cell morphology. Thus, removal of SO after reaching the desired tamponade effect is recommended.
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spelling pubmed-43076592015-02-09 Pars Plana Vitrectomy and Silicone Oil Injection in Phakic and Pseudophakic Eyes; Corneal Endothelial Changes Farrahi, Fereydoun Feghhi, Mostafa Ostadian, Farshad Alivand, Arash J Ophthalmic Vis Res Original Article PURPOSE: To evaluate the effect of silicone oil (SO) on the corneal endothelium in SO filled phakic and pseudophakic vitrectomizied eyes. METHODS: This prospective comparative consecutive case-control study evaluated the corneal endothelial characteristics of 64 SO filled vitrectomizied eyes (case group) as compared to 46 vitrectomizied eyes without SO injection (control group). Endothelial cell densities (ECD), coefficient of variation (CV), and percentage of hexagonal cells (hexagonality) at the corneal center were evaluated preoperatively, 1 month and 6 months after surgery using noncontact specular microscopy and were compared between the two groups. Exclusion criteria were previous vitreoretinal surgery, aphakia, any degree of anterior chamber inflammation, SO bubbles in the anterior chamber and increased intraocular pressure in the postoperative period. RESULTS: Six months after SO injection, mean ECD was 2,438.2±327.6 cell/mm(2) in the case group and 2,462.6±361.7 cell/mm(2) in the control group (P = 0.714) and mean hexagonality was 49.6 ± 6.8 and 54.6 ± 8.9, in the case and control groups, respectively (P = 0.004). Six months after operation, CV in the case group was 39.3 ± 5.6 and that in the control group was 35.7 ± 6.4 (P = 0.003). CONCLUSION: Although the presence of SO in the vitreous cavity of phakic and pseudophakic eyes causes slight reduction in the number of endothelial cells, however it leads to significant changes in endothelial cell morphology. Thus, removal of SO after reaching the desired tamponade effect is recommended. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4307659/ /pubmed/25667730 http://dx.doi.org/10.4103/2008-322X.143361 Text en Copyright: © Journal of Ophthalmic and Vision Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Farrahi, Fereydoun
Feghhi, Mostafa
Ostadian, Farshad
Alivand, Arash
Pars Plana Vitrectomy and Silicone Oil Injection in Phakic and Pseudophakic Eyes; Corneal Endothelial Changes
title Pars Plana Vitrectomy and Silicone Oil Injection in Phakic and Pseudophakic Eyes; Corneal Endothelial Changes
title_full Pars Plana Vitrectomy and Silicone Oil Injection in Phakic and Pseudophakic Eyes; Corneal Endothelial Changes
title_fullStr Pars Plana Vitrectomy and Silicone Oil Injection in Phakic and Pseudophakic Eyes; Corneal Endothelial Changes
title_full_unstemmed Pars Plana Vitrectomy and Silicone Oil Injection in Phakic and Pseudophakic Eyes; Corneal Endothelial Changes
title_short Pars Plana Vitrectomy and Silicone Oil Injection in Phakic and Pseudophakic Eyes; Corneal Endothelial Changes
title_sort pars plana vitrectomy and silicone oil injection in phakic and pseudophakic eyes; corneal endothelial changes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307659/
https://www.ncbi.nlm.nih.gov/pubmed/25667730
http://dx.doi.org/10.4103/2008-322X.143361
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