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The potential and challenges of using stem cells for cardiovascular repair and regeneration
Recent progress in using stem cells for tissue repair and functional restoration has aroused much attention due to its potential to provide a cue for many diseases such as myocardial infarction. Stem cell therapy for cardiovascular disease has been studied extensively at both experimental and clinic...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chongqing Medical University
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307803/ https://www.ncbi.nlm.nih.gov/pubmed/25642448 http://dx.doi.org/10.1016/j.gendis.2014.07.003 |
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author | Sun, Qisi Zhang, Zhonge Sun, Zhongjie |
author_facet | Sun, Qisi Zhang, Zhonge Sun, Zhongjie |
author_sort | Sun, Qisi |
collection | PubMed |
description | Recent progress in using stem cells for tissue repair and functional restoration has aroused much attention due to its potential to provide a cue for many diseases such as myocardial infarction. Stem cell therapy for cardiovascular disease has been studied extensively at both experimental and clinical levels. Pluripotent stem cells and mesenchymal stem cells were proven to be effective for myocardial regeneration, angiogenesis, and cardiac functional restoration. In this review, we will concisely discuss advantages and disadvantages of currently-used stem cells for cardiovascular repair and regeneration. The limitations and uniqueness of some types of stem cells will also be discussed. Although substantial progress has been made over the last decade about stem cells in cardiovascular regeneration, many challenges lie ahead before the therapeutic potentials of stem cells can be fully recognized. |
format | Online Article Text |
id | pubmed-4307803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Chongqing Medical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-43078032015-09-01 The potential and challenges of using stem cells for cardiovascular repair and regeneration Sun, Qisi Zhang, Zhonge Sun, Zhongjie Genes Dis Article Recent progress in using stem cells for tissue repair and functional restoration has aroused much attention due to its potential to provide a cue for many diseases such as myocardial infarction. Stem cell therapy for cardiovascular disease has been studied extensively at both experimental and clinical levels. Pluripotent stem cells and mesenchymal stem cells were proven to be effective for myocardial regeneration, angiogenesis, and cardiac functional restoration. In this review, we will concisely discuss advantages and disadvantages of currently-used stem cells for cardiovascular repair and regeneration. The limitations and uniqueness of some types of stem cells will also be discussed. Although substantial progress has been made over the last decade about stem cells in cardiovascular regeneration, many challenges lie ahead before the therapeutic potentials of stem cells can be fully recognized. Chongqing Medical University 2014-07-28 /pmc/articles/PMC4307803/ /pubmed/25642448 http://dx.doi.org/10.1016/j.gendis.2014.07.003 Text en Copyright © 2014, Chongqing Medical University. Production and hosting by Elsevier B.V. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
spellingShingle | Article Sun, Qisi Zhang, Zhonge Sun, Zhongjie The potential and challenges of using stem cells for cardiovascular repair and regeneration |
title | The potential and challenges of using stem cells for cardiovascular repair and regeneration |
title_full | The potential and challenges of using stem cells for cardiovascular repair and regeneration |
title_fullStr | The potential and challenges of using stem cells for cardiovascular repair and regeneration |
title_full_unstemmed | The potential and challenges of using stem cells for cardiovascular repair and regeneration |
title_short | The potential and challenges of using stem cells for cardiovascular repair and regeneration |
title_sort | potential and challenges of using stem cells for cardiovascular repair and regeneration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307803/ https://www.ncbi.nlm.nih.gov/pubmed/25642448 http://dx.doi.org/10.1016/j.gendis.2014.07.003 |
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