Seizure control and improvement of neurological dysfunction in Lafora disease with perampanel

Lafora disease is a rare and fatal disease characterized by seizures, progressive cognitive and behavioral deterioration, as well as cerebellar dysfunction. Currently, there is no efficacious treatment that will control the seizures and improve the cognitive decline in this disease. We report a pati...

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Detalles Bibliográficos
Autores principales: Dirani, Maya, Nasreddine, Wassim, Abdulla, Fatima, Beydoun, Ahmad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307869/
https://www.ncbi.nlm.nih.gov/pubmed/25667898
http://dx.doi.org/10.1016/j.ebcr.2014.09.003
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author Dirani, Maya
Nasreddine, Wassim
Abdulla, Fatima
Beydoun, Ahmad
author_facet Dirani, Maya
Nasreddine, Wassim
Abdulla, Fatima
Beydoun, Ahmad
author_sort Dirani, Maya
collection PubMed
description Lafora disease is a rare and fatal disease characterized by seizures, progressive cognitive and behavioral deterioration, as well as cerebellar dysfunction. Currently, there is no efficacious treatment that will control the seizures and improve the cognitive decline in this disease. We report a patient with Lafora disease who experienced a dramatic amelioration in her seizure frequency as well as the associated neurological and cognitive dysfunction following initiation of treatment with perampanel administered as monotherapy. Perampanel is the first potentially efficacious treatment for Lafora disease. We discuss a potential mechanism for the efficacy of perampanel in this disease.
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spelling pubmed-43078692015-02-09 Seizure control and improvement of neurological dysfunction in Lafora disease with perampanel Dirani, Maya Nasreddine, Wassim Abdulla, Fatima Beydoun, Ahmad Epilepsy Behav Case Rep Case Report Lafora disease is a rare and fatal disease characterized by seizures, progressive cognitive and behavioral deterioration, as well as cerebellar dysfunction. Currently, there is no efficacious treatment that will control the seizures and improve the cognitive decline in this disease. We report a patient with Lafora disease who experienced a dramatic amelioration in her seizure frequency as well as the associated neurological and cognitive dysfunction following initiation of treatment with perampanel administered as monotherapy. Perampanel is the first potentially efficacious treatment for Lafora disease. We discuss a potential mechanism for the efficacy of perampanel in this disease. Elsevier 2014-09-29 /pmc/articles/PMC4307869/ /pubmed/25667898 http://dx.doi.org/10.1016/j.ebcr.2014.09.003 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Case Report
Dirani, Maya
Nasreddine, Wassim
Abdulla, Fatima
Beydoun, Ahmad
Seizure control and improvement of neurological dysfunction in Lafora disease with perampanel
title Seizure control and improvement of neurological dysfunction in Lafora disease with perampanel
title_full Seizure control and improvement of neurological dysfunction in Lafora disease with perampanel
title_fullStr Seizure control and improvement of neurological dysfunction in Lafora disease with perampanel
title_full_unstemmed Seizure control and improvement of neurological dysfunction in Lafora disease with perampanel
title_short Seizure control and improvement of neurological dysfunction in Lafora disease with perampanel
title_sort seizure control and improvement of neurological dysfunction in lafora disease with perampanel
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307869/
https://www.ncbi.nlm.nih.gov/pubmed/25667898
http://dx.doi.org/10.1016/j.ebcr.2014.09.003
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