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EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex

BACKGROUND: Epithelial cell adhesion molecule (EpCAM) is overexpressed in solid tumors and regarded as a putative cancer stem cell marker. Here, we report that employing EpCAM aptamer (EpApt) and EpCAM siRNA (SiEp) dual approach, for the targeted delivery of siRNA to EpCAM positive cancer cells, eff...

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Detalles Bibliográficos
Autores principales:	Subramanian, Nithya, Kanwar, Jagat R, Athalya, Prasanna kumar, Janakiraman, Narayanan, Khetan, Vikas, Kanwar, Rupinder K, Eluchuri, Sailaja, Krishnakumar, Subramanian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307906/ https://www.ncbi.nlm.nih.gov/pubmed/25576037 http://dx.doi.org/10.1186/s12929-014-0108-9

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