Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia

BACKGROUND: One of the most frequently found abnormalities in acute myeloid leukemia (AML) is the t(8;21)(q22;q22) translocation, which is seen in around 15% of patients. This translocation results in the production of the AML1/ETO (A/E) fusion protein and commonly involves cooperating activating mu...

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Detalles Bibliográficos
Autores principales: Salmon, Jessica M, Bots, Michael, Vidacs, Eva, Stanley, Kym L, Atadja, Peter, Zuber, Johannes, Johnstone, Ricky W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308003/
https://www.ncbi.nlm.nih.gov/pubmed/25628765
http://dx.doi.org/10.1186/s13148-014-0034-4

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