Cargando…

Exercise-induced seizures and lateral asymmetry in patients with temporal lobe epilepsy()()

OBJECTIVE: The objective of this case report is to better characterize the clinical features and potential pathophysiological mechanisms of exercise-induced seizures. METHODS: We report a case series of ten patients from a tertiary epilepsy center, where a clear history was obtained of physical exer...

Descripción completa

Detalles Bibliográficos
Autores principales: Kamel, Jordan T., Badawy, Radwa A.B., Cook, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308088/
https://www.ncbi.nlm.nih.gov/pubmed/25667863
http://dx.doi.org/10.1016/j.ebcr.2013.12.004
_version_ 1782354547352535040
author Kamel, Jordan T.
Badawy, Radwa A.B.
Cook, Mark J.
author_facet Kamel, Jordan T.
Badawy, Radwa A.B.
Cook, Mark J.
author_sort Kamel, Jordan T.
collection PubMed
description OBJECTIVE: The objective of this case report is to better characterize the clinical features and potential pathophysiological mechanisms of exercise-induced seizures. METHODS: We report a case series of ten patients from a tertiary epilepsy center, where a clear history was obtained of physical exercise as a reproducible trigger for seizures. RESULTS: The precipitating type of exercise was quite specific for each patient, and various forms of exercise are described including running, swimming, playing netball, dancing, cycling, weight lifting, and martial arts. The level of physical exertion also correlated with the likelihood of seizure occurrence. All ten patients had temporal lobe abnormalities, with nine of the ten patients having isolated temporal lobe epilepsies, as supported by seizure semiology, EEG recordings, and both structural and functional imaging. Nine of the ten patients had seizures that were lateralized to the left (dominant) hemisphere. Five patients underwent surgical resection, with no successful long-term postoperative outcomes. CONCLUSIONS: Exercise may be an underrecognized form of reflex epilepsy, which tended to be refractory to both medical and surgical interventions in our patients. Almost all patients in our cohort had seizures localizing to the left temporal lobe. We discuss potential mechanisms by which exercise may precipitate seizures, and its relevance regarding our understanding of temporal lobe epilepsy and lateralization of seizures. Recognition of, as well as advice regarding avoidance of, known triggers forms an important part of management of these patients.
format Online
Article
Text
id pubmed-4308088
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-43080882015-02-09 Exercise-induced seizures and lateral asymmetry in patients with temporal lobe epilepsy()() Kamel, Jordan T. Badawy, Radwa A.B. Cook, Mark J. Epilepsy Behav Case Rep Case Report OBJECTIVE: The objective of this case report is to better characterize the clinical features and potential pathophysiological mechanisms of exercise-induced seizures. METHODS: We report a case series of ten patients from a tertiary epilepsy center, where a clear history was obtained of physical exercise as a reproducible trigger for seizures. RESULTS: The precipitating type of exercise was quite specific for each patient, and various forms of exercise are described including running, swimming, playing netball, dancing, cycling, weight lifting, and martial arts. The level of physical exertion also correlated with the likelihood of seizure occurrence. All ten patients had temporal lobe abnormalities, with nine of the ten patients having isolated temporal lobe epilepsies, as supported by seizure semiology, EEG recordings, and both structural and functional imaging. Nine of the ten patients had seizures that were lateralized to the left (dominant) hemisphere. Five patients underwent surgical resection, with no successful long-term postoperative outcomes. CONCLUSIONS: Exercise may be an underrecognized form of reflex epilepsy, which tended to be refractory to both medical and surgical interventions in our patients. Almost all patients in our cohort had seizures localizing to the left temporal lobe. We discuss potential mechanisms by which exercise may precipitate seizures, and its relevance regarding our understanding of temporal lobe epilepsy and lateralization of seizures. Recognition of, as well as advice regarding avoidance of, known triggers forms an important part of management of these patients. Elsevier 2014-02-01 /pmc/articles/PMC4308088/ /pubmed/25667863 http://dx.doi.org/10.1016/j.ebcr.2013.12.004 Text en © 2013 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Case Report
Kamel, Jordan T.
Badawy, Radwa A.B.
Cook, Mark J.
Exercise-induced seizures and lateral asymmetry in patients with temporal lobe epilepsy()()
title Exercise-induced seizures and lateral asymmetry in patients with temporal lobe epilepsy()()
title_full Exercise-induced seizures and lateral asymmetry in patients with temporal lobe epilepsy()()
title_fullStr Exercise-induced seizures and lateral asymmetry in patients with temporal lobe epilepsy()()
title_full_unstemmed Exercise-induced seizures and lateral asymmetry in patients with temporal lobe epilepsy()()
title_short Exercise-induced seizures and lateral asymmetry in patients with temporal lobe epilepsy()()
title_sort exercise-induced seizures and lateral asymmetry in patients with temporal lobe epilepsy()()
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308088/
https://www.ncbi.nlm.nih.gov/pubmed/25667863
http://dx.doi.org/10.1016/j.ebcr.2013.12.004
work_keys_str_mv AT kameljordant exerciseinducedseizuresandlateralasymmetryinpatientswithtemporallobeepilepsy
AT badawyradwaab exerciseinducedseizuresandlateralasymmetryinpatientswithtemporallobeepilepsy
AT cookmarkj exerciseinducedseizuresandlateralasymmetryinpatientswithtemporallobeepilepsy