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A Novel Simple Method for Determining CYP2D6 Gene Copy Number and Identifying Allele(s) with Duplication/Multiplication

BACKGROUND: Cytochrome P450 2D6 (CYP2D6) gene duplication and multiplication can result in ultrarapid drug metabolism and therapeutic failure or excessive response in patients. Long range polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP) and sequencing are usually used...

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Detalles Bibliográficos
Autores principales:	Langaee, Taimour, Hamadeh, Issam, Chapman, Arlene B., Gums, John G., Johnson, Julie A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308104/ https://www.ncbi.nlm.nih.gov/pubmed/25625348 http://dx.doi.org/10.1371/journal.pone.0113808

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