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Dysgenesis of Enteroendocrine Cells in Aristaless-Related Homeobox Polyalanine Expansion Mutations

OBJECTIVES: Severe congenital diarrhea occurs in approximately half of patients with Aristaless-Related Homeobox (ARX) null mutations. The cause of this diarrhea is unknown. In a mouse model of intestinal Arx deficiency, the prevalence of a subset of enteroendocrine cells is altered, leading to diar...

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Detalles Bibliográficos
Autores principales: Terry, Natalie A., Lee, Randall A., Walp, Erik R., Kaestner, Klaus H., Lee May, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308495/
https://www.ncbi.nlm.nih.gov/pubmed/25171319
http://dx.doi.org/10.1097/MPG.0000000000000542

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