Na(v)1.7 protein and mRNA expression in the dorsal root ganglia of rats with chronic neuropathic pain★

Neuropathic pain was produced by chronic constriction injury of the sciatic nerve in rats. Behavioral tests showed that the thresholds for thermal and mechanical hyperalgesia were significantly reduced in neuropathic pain rats 3–28 days following model induction. The results of immunohistochemistry,...

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Detalles Bibliográficos
Autores principales: Liu, Chao, Cao, Jing, Ren, Xiuhua, Zang, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research and Report: Spinal Cord Injury and Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308749/
https://www.ncbi.nlm.nih.gov/pubmed/25657691
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.20.003
Descripción
Sumario:Neuropathic pain was produced by chronic constriction injury of the sciatic nerve in rats. Behavioral tests showed that the thresholds for thermal and mechanical hyperalgesia were significantly reduced in neuropathic pain rats 3–28 days following model induction. The results of immunohistochemistry, western blot assays and reverse transcription-PCR showed that Na(v)1.7 protein and mRNA expression was significantly increased in the injured dorsal root ganglia. These findings indicated that Na(v)1.7 might play an important role in the model of chronic neuropathic pain.

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