Na(v)1.7 protein and mRNA expression in the dorsal root ganglia of rats with chronic neuropathic pain★

Neuropathic pain was produced by chronic constriction injury of the sciatic nerve in rats. Behavioral tests showed that the thresholds for thermal and mechanical hyperalgesia were significantly reduced in neuropathic pain rats 3–28 days following model induction. The results of immunohistochemistry,...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Chao, Cao, Jing, Ren, Xiuhua, Zang, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research and Report: Spinal Cord Injury and Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308749/
https://www.ncbi.nlm.nih.gov/pubmed/25657691
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.20.003
_version_ 1782354575641018368
author Liu, Chao
Cao, Jing
Ren, Xiuhua
Zang, Weidong
author_facet Liu, Chao
Cao, Jing
Ren, Xiuhua
Zang, Weidong
author_sort Liu, Chao
collection PubMed
description Neuropathic pain was produced by chronic constriction injury of the sciatic nerve in rats. Behavioral tests showed that the thresholds for thermal and mechanical hyperalgesia were significantly reduced in neuropathic pain rats 3–28 days following model induction. The results of immunohistochemistry, western blot assays and reverse transcription-PCR showed that Na(v)1.7 protein and mRNA expression was significantly increased in the injured dorsal root ganglia. These findings indicated that Na(v)1.7 might play an important role in the model of chronic neuropathic pain.
format Online
Article
Text
id pubmed-4308749
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-43087492015-02-05 Na(v)1.7 protein and mRNA expression in the dorsal root ganglia of rats with chronic neuropathic pain★ Liu, Chao Cao, Jing Ren, Xiuhua Zang, Weidong Neural Regen Res Research and Report: Spinal Cord Injury and Neural Regeneration Neuropathic pain was produced by chronic constriction injury of the sciatic nerve in rats. Behavioral tests showed that the thresholds for thermal and mechanical hyperalgesia were significantly reduced in neuropathic pain rats 3–28 days following model induction. The results of immunohistochemistry, western blot assays and reverse transcription-PCR showed that Na(v)1.7 protein and mRNA expression was significantly increased in the injured dorsal root ganglia. These findings indicated that Na(v)1.7 might play an important role in the model of chronic neuropathic pain. Medknow Publications & Media Pvt Ltd 2012-07-15 /pmc/articles/PMC4308749/ /pubmed/25657691 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.20.003 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report: Spinal Cord Injury and Neural Regeneration
Liu, Chao
Cao, Jing
Ren, Xiuhua
Zang, Weidong
Na(v)1.7 protein and mRNA expression in the dorsal root ganglia of rats with chronic neuropathic pain★
title Na(v)1.7 protein and mRNA expression in the dorsal root ganglia of rats with chronic neuropathic pain★
title_full Na(v)1.7 protein and mRNA expression in the dorsal root ganglia of rats with chronic neuropathic pain★
title_fullStr Na(v)1.7 protein and mRNA expression in the dorsal root ganglia of rats with chronic neuropathic pain★
title_full_unstemmed Na(v)1.7 protein and mRNA expression in the dorsal root ganglia of rats with chronic neuropathic pain★
title_short Na(v)1.7 protein and mRNA expression in the dorsal root ganglia of rats with chronic neuropathic pain★
title_sort na(v)1.7 protein and mrna expression in the dorsal root ganglia of rats with chronic neuropathic pain★
topic Research and Report: Spinal Cord Injury and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308749/
https://www.ncbi.nlm.nih.gov/pubmed/25657691
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.20.003
work_keys_str_mv AT liuchao nav17proteinandmrnaexpressioninthedorsalrootgangliaofratswithchronicneuropathicpain
AT caojing nav17proteinandmrnaexpressioninthedorsalrootgangliaofratswithchronicneuropathicpain
AT renxiuhua nav17proteinandmrnaexpressioninthedorsalrootgangliaofratswithchronicneuropathicpain
AT zangweidong nav17proteinandmrnaexpressioninthedorsalrootgangliaofratswithchronicneuropathicpain

Ejemplares similares