Effects of injection of anti-corticotropin release hormone serum in the lateral ventricles and electroacupuncture analgesia on pain threshold in rats with adjuvant arthritis☆

Rat models of adjuvant arthritis were established, and anti-corticotropin release hormone serum injection in the lateral ventricles and electroacupuncture at right Jiaji (EX-B2) were performed. The pain threshold was decreased at 45 and 60 minutes after injection of the anti-corticotropin release ho...

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Autores principales: Qiao, Yunying, Wu, Fudong, Wang, Jian, Cui, Xiaolu, Liu, Congcong, Zhu, Xinlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research and Report: Acupuncture and Moxibustion and Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308765/
https://www.ncbi.nlm.nih.gov/pubmed/25657703
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.21.005
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author Qiao, Yunying
Wu, Fudong
Wang, Jian
Cui, Xiaolu
Liu, Congcong
Zhu, Xinlong
author_facet Qiao, Yunying
Wu, Fudong
Wang, Jian
Cui, Xiaolu
Liu, Congcong
Zhu, Xinlong
author_sort Qiao, Yunying
collection PubMed
description Rat models of adjuvant arthritis were established, and anti-corticotropin release hormone serum injection in the lateral ventricles and electroacupuncture at right Jiaji (EX-B2) were performed. The pain threshold was decreased at 45 and 60 minutes after injection of the anti-corticotropin release hormone serum. Electroacupuncture at Jiaji can resist this effect. Immunohistochemical staining results showed that the expression of corticotropin release hormone in the hypothalamic paraventricular nucleus was greater in the electroacupuncture + anti-corticotropin release hormone serum group compared with the anti-corticotropin release hormone serum group. The expression of corticotropin release hormone was correlated with the pain threshold. The effect of endogenous corticotropin release hormone in pain modulation can be obstructed by anti-corticotropin release hormone serum. The analgesia of electroacupuncture can partially resist the depressed pain threshold caused by injection of anti-corticotropin release hormone serum. The analgesic effect of electroacupuncture is associated with the corticotropin release hormone content in the hypothalamus.
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spelling pubmed-43087652015-02-05 Effects of injection of anti-corticotropin release hormone serum in the lateral ventricles and electroacupuncture analgesia on pain threshold in rats with adjuvant arthritis☆ Qiao, Yunying Wu, Fudong Wang, Jian Cui, Xiaolu Liu, Congcong Zhu, Xinlong Neural Regen Res Research and Report: Acupuncture and Moxibustion and Neural Regeneration Rat models of adjuvant arthritis were established, and anti-corticotropin release hormone serum injection in the lateral ventricles and electroacupuncture at right Jiaji (EX-B2) were performed. The pain threshold was decreased at 45 and 60 minutes after injection of the anti-corticotropin release hormone serum. Electroacupuncture at Jiaji can resist this effect. Immunohistochemical staining results showed that the expression of corticotropin release hormone in the hypothalamic paraventricular nucleus was greater in the electroacupuncture + anti-corticotropin release hormone serum group compared with the anti-corticotropin release hormone serum group. The expression of corticotropin release hormone was correlated with the pain threshold. The effect of endogenous corticotropin release hormone in pain modulation can be obstructed by anti-corticotropin release hormone serum. The analgesia of electroacupuncture can partially resist the depressed pain threshold caused by injection of anti-corticotropin release hormone serum. The analgesic effect of electroacupuncture is associated with the corticotropin release hormone content in the hypothalamus. Medknow Publications & Media Pvt Ltd 2012-07-25 /pmc/articles/PMC4308765/ /pubmed/25657703 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.21.005 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report: Acupuncture and Moxibustion and Neural Regeneration
Qiao, Yunying
Wu, Fudong
Wang, Jian
Cui, Xiaolu
Liu, Congcong
Zhu, Xinlong
Effects of injection of anti-corticotropin release hormone serum in the lateral ventricles and electroacupuncture analgesia on pain threshold in rats with adjuvant arthritis☆
title Effects of injection of anti-corticotropin release hormone serum in the lateral ventricles and electroacupuncture analgesia on pain threshold in rats with adjuvant arthritis☆
title_full Effects of injection of anti-corticotropin release hormone serum in the lateral ventricles and electroacupuncture analgesia on pain threshold in rats with adjuvant arthritis☆
title_fullStr Effects of injection of anti-corticotropin release hormone serum in the lateral ventricles and electroacupuncture analgesia on pain threshold in rats with adjuvant arthritis☆
title_full_unstemmed Effects of injection of anti-corticotropin release hormone serum in the lateral ventricles and electroacupuncture analgesia on pain threshold in rats with adjuvant arthritis☆
title_short Effects of injection of anti-corticotropin release hormone serum in the lateral ventricles and electroacupuncture analgesia on pain threshold in rats with adjuvant arthritis☆
title_sort effects of injection of anti-corticotropin release hormone serum in the lateral ventricles and electroacupuncture analgesia on pain threshold in rats with adjuvant arthritis☆
topic Research and Report: Acupuncture and Moxibustion and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308765/
https://www.ncbi.nlm.nih.gov/pubmed/25657703
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.21.005
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