Effect of propofol on brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus of aged rats with chronic cerebral ischemia☆

We intraperitoneally injected 10 and 50 mg/kg of propofol for 7 consecutive days to treat a rat model of chronic cerebral ischemia. A low-dose of propofol promoted the expression of brain-derived neurotrophic factor, tyrosine kinase receptor B, phosphorylated cAMP response element binding protein, a...

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Autores principales: Chen, Gang, Fu, Qiang, Cao, Jiangbei, Mi, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Techniques and Method: Emerging Technology in Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308767/
https://www.ncbi.nlm.nih.gov/pubmed/25657705
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.21.007
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author Chen, Gang
Fu, Qiang
Cao, Jiangbei
Mi, Weidong
author_facet Chen, Gang
Fu, Qiang
Cao, Jiangbei
Mi, Weidong
author_sort Chen, Gang
collection PubMed
description We intraperitoneally injected 10 and 50 mg/kg of propofol for 7 consecutive days to treat a rat model of chronic cerebral ischemia. A low-dose of propofol promoted the expression of brain-derived neurotrophic factor, tyrosine kinase receptor B, phosphorylated cAMP response element binding protein, and cAMP in the hippocampus of aged rats with chronic cerebral ischemia, but a high-dose of propofol inhibited their expression. Results indicated that the protective effect of propofol against cerebral ischemia in aged rats is related to changes in the expression of brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus, and that the cAMP-cAMP responsive element binding protein pathway is involved in the regulatory effect of propofol on brain-derived neurotrophic factor expression.
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spelling pubmed-43087672015-02-05 Effect of propofol on brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus of aged rats with chronic cerebral ischemia☆ Chen, Gang Fu, Qiang Cao, Jiangbei Mi, Weidong Neural Regen Res Techniques and Method: Emerging Technology in Neural Regeneration We intraperitoneally injected 10 and 50 mg/kg of propofol for 7 consecutive days to treat a rat model of chronic cerebral ischemia. A low-dose of propofol promoted the expression of brain-derived neurotrophic factor, tyrosine kinase receptor B, phosphorylated cAMP response element binding protein, and cAMP in the hippocampus of aged rats with chronic cerebral ischemia, but a high-dose of propofol inhibited their expression. Results indicated that the protective effect of propofol against cerebral ischemia in aged rats is related to changes in the expression of brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus, and that the cAMP-cAMP responsive element binding protein pathway is involved in the regulatory effect of propofol on brain-derived neurotrophic factor expression. Medknow Publications & Media Pvt Ltd 2012-07-25 /pmc/articles/PMC4308767/ /pubmed/25657705 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.21.007 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Techniques and Method: Emerging Technology in Neural Regeneration
Chen, Gang
Fu, Qiang
Cao, Jiangbei
Mi, Weidong
Effect of propofol on brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus of aged rats with chronic cerebral ischemia☆
title Effect of propofol on brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus of aged rats with chronic cerebral ischemia☆
title_full Effect of propofol on brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus of aged rats with chronic cerebral ischemia☆
title_fullStr Effect of propofol on brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus of aged rats with chronic cerebral ischemia☆
title_full_unstemmed Effect of propofol on brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus of aged rats with chronic cerebral ischemia☆
title_short Effect of propofol on brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus of aged rats with chronic cerebral ischemia☆
title_sort effect of propofol on brain-derived neurotrophic factor and tyrosine kinase receptor b in the hippocampus of aged rats with chronic cerebral ischemia☆
topic Techniques and Method: Emerging Technology in Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308767/
https://www.ncbi.nlm.nih.gov/pubmed/25657705
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.21.007
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