Changes in the default mode network in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users★

The default mode network is associated with senior cognitive functions in humans. In this study, we performed independent component analysis of blood oxygenation signals from 14 heroin users and 13 matched normal controls in the resting state through functional MRI scans. Results showed that the def...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Wenfu, Fu, Xiangming, Qian, Ruobing, Wei, Xiangpin, Ji, Xuebing, Niu, Chaoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Techniques and Method: Neuroimaging and Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308788/
https://www.ncbi.nlm.nih.gov/pubmed/25657671
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.18.004
_version_ 1782354585076105216
author Hu, Wenfu
Fu, Xiangming
Qian, Ruobing
Wei, Xiangpin
Ji, Xuebing
Niu, Chaoshi
author_facet Hu, Wenfu
Fu, Xiangming
Qian, Ruobing
Wei, Xiangpin
Ji, Xuebing
Niu, Chaoshi
author_sort Hu, Wenfu
collection PubMed
description The default mode network is associated with senior cognitive functions in humans. In this study, we performed independent component analysis of blood oxygenation signals from 14 heroin users and 13 matched normal controls in the resting state through functional MRI scans. Results showed that the default mode network was significantly activated in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users, and an enhanced activation signal was observed in the right inferior parietal lobule (P < 0.05, corrected for false discovery rate). Experimental findings indicate that the default mode network is altered in heroin users.
format Online
Article
Text
id pubmed-4308788
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-43087882015-02-05 Changes in the default mode network in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users★ Hu, Wenfu Fu, Xiangming Qian, Ruobing Wei, Xiangpin Ji, Xuebing Niu, Chaoshi Neural Regen Res Techniques and Method: Neuroimaging and Neural Regeneration The default mode network is associated with senior cognitive functions in humans. In this study, we performed independent component analysis of blood oxygenation signals from 14 heroin users and 13 matched normal controls in the resting state through functional MRI scans. Results showed that the default mode network was significantly activated in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users, and an enhanced activation signal was observed in the right inferior parietal lobule (P < 0.05, corrected for false discovery rate). Experimental findings indicate that the default mode network is altered in heroin users. Medknow Publications & Media Pvt Ltd 2012-06-25 /pmc/articles/PMC4308788/ /pubmed/25657671 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.18.004 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Techniques and Method: Neuroimaging and Neural Regeneration
Hu, Wenfu
Fu, Xiangming
Qian, Ruobing
Wei, Xiangpin
Ji, Xuebing
Niu, Chaoshi
Changes in the default mode network in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users★
title Changes in the default mode network in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users★
title_full Changes in the default mode network in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users★
title_fullStr Changes in the default mode network in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users★
title_full_unstemmed Changes in the default mode network in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users★
title_short Changes in the default mode network in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users★
title_sort changes in the default mode network in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users★
topic Techniques and Method: Neuroimaging and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308788/
https://www.ncbi.nlm.nih.gov/pubmed/25657671
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.18.004
work_keys_str_mv AT huwenfu changesinthedefaultmodenetworkintheprefrontallobeposteriorcingulatedcortexandhippocampusofheroinusers
AT fuxiangming changesinthedefaultmodenetworkintheprefrontallobeposteriorcingulatedcortexandhippocampusofheroinusers
AT qianruobing changesinthedefaultmodenetworkintheprefrontallobeposteriorcingulatedcortexandhippocampusofheroinusers
AT weixiangpin changesinthedefaultmodenetworkintheprefrontallobeposteriorcingulatedcortexandhippocampusofheroinusers
AT jixuebing changesinthedefaultmodenetworkintheprefrontallobeposteriorcingulatedcortexandhippocampusofheroinusers
AT niuchaoshi changesinthedefaultmodenetworkintheprefrontallobeposteriorcingulatedcortexandhippocampusofheroinusers

Ejemplares similares