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L-tyrosine improves neuroendocrine function in a mouse model of chronic stress

Adult BALB/c mice, individually housed, were stimulated with nine different stressors, arranged randomly, for 4 continuous weeks to generate an animal model of chronic stress. In chronically stressed mice, spontaneous locomotor activity was significantly decreased, escape latency in the Morris water...

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Autores principales: Wang, Zhihua, Li, Jinghua, Wang, Zhiming, Xue, Lingyan, Zhang, Yi, Chen, Yingjie, Su, Jun, Li, Zhongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308793/
https://www.ncbi.nlm.nih.gov/pubmed/25657675
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.18.008
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author Wang, Zhihua
Li, Jinghua
Wang, Zhiming
Xue, Lingyan
Zhang, Yi
Chen, Yingjie
Su, Jun
Li, Zhongming
author_facet Wang, Zhihua
Li, Jinghua
Wang, Zhiming
Xue, Lingyan
Zhang, Yi
Chen, Yingjie
Su, Jun
Li, Zhongming
author_sort Wang, Zhihua
collection PubMed
description Adult BALB/c mice, individually housed, were stimulated with nine different stressors, arranged randomly, for 4 continuous weeks to generate an animal model of chronic stress. In chronically stressed mice, spontaneous locomotor activity was significantly decreased, escape latency in the Morris water maze test was prolonged, serum levels of total thyrotropin and total triiodothyronine were significantly decreased, and dopamine and norepinephrine content in the pallium, hippocampus and hypothalamus were significantly reduced. All of these changes were suppressed, to varying degrees, by L-tyrosine supplementation. These findings indicate that the neuroendocrine network plays an important role in chronic stress, and that L-tyrosine supplementation has therapeutic effects.
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spelling pubmed-43087932015-02-05 L-tyrosine improves neuroendocrine function in a mouse model of chronic stress Wang, Zhihua Li, Jinghua Wang, Zhiming Xue, Lingyan Zhang, Yi Chen, Yingjie Su, Jun Li, Zhongming Neural Regen Res Techniques and Method: Emerging Technology in Neural Regeneration Adult BALB/c mice, individually housed, were stimulated with nine different stressors, arranged randomly, for 4 continuous weeks to generate an animal model of chronic stress. In chronically stressed mice, spontaneous locomotor activity was significantly decreased, escape latency in the Morris water maze test was prolonged, serum levels of total thyrotropin and total triiodothyronine were significantly decreased, and dopamine and norepinephrine content in the pallium, hippocampus and hypothalamus were significantly reduced. All of these changes were suppressed, to varying degrees, by L-tyrosine supplementation. These findings indicate that the neuroendocrine network plays an important role in chronic stress, and that L-tyrosine supplementation has therapeutic effects. Medknow Publications & Media Pvt Ltd 2012-06-25 /pmc/articles/PMC4308793/ /pubmed/25657675 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.18.008 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Techniques and Method: Emerging Technology in Neural Regeneration
Wang, Zhihua
Li, Jinghua
Wang, Zhiming
Xue, Lingyan
Zhang, Yi
Chen, Yingjie
Su, Jun
Li, Zhongming
L-tyrosine improves neuroendocrine function in a mouse model of chronic stress
title L-tyrosine improves neuroendocrine function in a mouse model of chronic stress
title_full L-tyrosine improves neuroendocrine function in a mouse model of chronic stress
title_fullStr L-tyrosine improves neuroendocrine function in a mouse model of chronic stress
title_full_unstemmed L-tyrosine improves neuroendocrine function in a mouse model of chronic stress
title_short L-tyrosine improves neuroendocrine function in a mouse model of chronic stress
title_sort l-tyrosine improves neuroendocrine function in a mouse model of chronic stress
topic Techniques and Method: Emerging Technology in Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308793/
https://www.ncbi.nlm.nih.gov/pubmed/25657675
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.18.008
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