Cargando…
L-tyrosine improves neuroendocrine function in a mouse model of chronic stress
Adult BALB/c mice, individually housed, were stimulated with nine different stressors, arranged randomly, for 4 continuous weeks to generate an animal model of chronic stress. In chronically stressed mice, spontaneous locomotor activity was significantly decreased, escape latency in the Morris water...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308793/ https://www.ncbi.nlm.nih.gov/pubmed/25657675 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.18.008 |
_version_ | 1782354586279870464 |
---|---|
author | Wang, Zhihua Li, Jinghua Wang, Zhiming Xue, Lingyan Zhang, Yi Chen, Yingjie Su, Jun Li, Zhongming |
author_facet | Wang, Zhihua Li, Jinghua Wang, Zhiming Xue, Lingyan Zhang, Yi Chen, Yingjie Su, Jun Li, Zhongming |
author_sort | Wang, Zhihua |
collection | PubMed |
description | Adult BALB/c mice, individually housed, were stimulated with nine different stressors, arranged randomly, for 4 continuous weeks to generate an animal model of chronic stress. In chronically stressed mice, spontaneous locomotor activity was significantly decreased, escape latency in the Morris water maze test was prolonged, serum levels of total thyrotropin and total triiodothyronine were significantly decreased, and dopamine and norepinephrine content in the pallium, hippocampus and hypothalamus were significantly reduced. All of these changes were suppressed, to varying degrees, by L-tyrosine supplementation. These findings indicate that the neuroendocrine network plays an important role in chronic stress, and that L-tyrosine supplementation has therapeutic effects. |
format | Online Article Text |
id | pubmed-4308793 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43087932015-02-05 L-tyrosine improves neuroendocrine function in a mouse model of chronic stress Wang, Zhihua Li, Jinghua Wang, Zhiming Xue, Lingyan Zhang, Yi Chen, Yingjie Su, Jun Li, Zhongming Neural Regen Res Techniques and Method: Emerging Technology in Neural Regeneration Adult BALB/c mice, individually housed, were stimulated with nine different stressors, arranged randomly, for 4 continuous weeks to generate an animal model of chronic stress. In chronically stressed mice, spontaneous locomotor activity was significantly decreased, escape latency in the Morris water maze test was prolonged, serum levels of total thyrotropin and total triiodothyronine were significantly decreased, and dopamine and norepinephrine content in the pallium, hippocampus and hypothalamus were significantly reduced. All of these changes were suppressed, to varying degrees, by L-tyrosine supplementation. These findings indicate that the neuroendocrine network plays an important role in chronic stress, and that L-tyrosine supplementation has therapeutic effects. Medknow Publications & Media Pvt Ltd 2012-06-25 /pmc/articles/PMC4308793/ /pubmed/25657675 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.18.008 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Techniques and Method: Emerging Technology in Neural Regeneration Wang, Zhihua Li, Jinghua Wang, Zhiming Xue, Lingyan Zhang, Yi Chen, Yingjie Su, Jun Li, Zhongming L-tyrosine improves neuroendocrine function in a mouse model of chronic stress |
title | L-tyrosine improves neuroendocrine function in a mouse model of chronic stress |
title_full | L-tyrosine improves neuroendocrine function in a mouse model of chronic stress |
title_fullStr | L-tyrosine improves neuroendocrine function in a mouse model of chronic stress |
title_full_unstemmed | L-tyrosine improves neuroendocrine function in a mouse model of chronic stress |
title_short | L-tyrosine improves neuroendocrine function in a mouse model of chronic stress |
title_sort | l-tyrosine improves neuroendocrine function in a mouse model of chronic stress |
topic | Techniques and Method: Emerging Technology in Neural Regeneration |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308793/ https://www.ncbi.nlm.nih.gov/pubmed/25657675 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.18.008 |
work_keys_str_mv | AT wangzhihua ltyrosineimprovesneuroendocrinefunctioninamousemodelofchronicstress AT lijinghua ltyrosineimprovesneuroendocrinefunctioninamousemodelofchronicstress AT wangzhiming ltyrosineimprovesneuroendocrinefunctioninamousemodelofchronicstress AT xuelingyan ltyrosineimprovesneuroendocrinefunctioninamousemodelofchronicstress AT zhangyi ltyrosineimprovesneuroendocrinefunctioninamousemodelofchronicstress AT chenyingjie ltyrosineimprovesneuroendocrinefunctioninamousemodelofchronicstress AT sujun ltyrosineimprovesneuroendocrinefunctioninamousemodelofchronicstress AT lizhongming ltyrosineimprovesneuroendocrinefunctioninamousemodelofchronicstress |