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Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy★

We treated detonator-explosion-induced craniocerebral injury in rabbits with hyperbaric oxygen 1-24 hours post-injury. Expression of the apoptosis-regulating protein cytochrome c, the pro-apoptotic protein Bax and the apoptosis marker caspase-3 in the tissues surrounding the area of injury was signi...

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Detalles Bibliográficos
Autores principales: Xu, Shaonian, Liu, Jiachuan, Zhang, Yongming, Wang, Chunlin, Wang, Jinbiao, Yang, Yanyan, Huo, Jian, Sun, Wenjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308802/
https://www.ncbi.nlm.nih.gov/pubmed/25657662
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.17.006
Descripción
Sumario:We treated detonator-explosion-induced craniocerebral injury in rabbits with hyperbaric oxygen 1-24 hours post-injury. Expression of the apoptosis-regulating protein cytochrome c, the pro-apoptotic protein Bax and the apoptosis marker caspase-3 in the tissues surrounding the area of injury was significantly reduced, while that of the anti-apoptotic protein Bcl-2 was significantly increased. Our findings indicate that the curative effects of early hyperbaric oxygen on cortical cell apoptosis is associated with suppression of cytochrome c release from mitochondria. This mechanism underlies the observed reduction in Bax expression and upregulation of Bcl-2 expression.