Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy★

We treated detonator-explosion-induced craniocerebral injury in rabbits with hyperbaric oxygen 1-24 hours post-injury. Expression of the apoptosis-regulating protein cytochrome c, the pro-apoptotic protein Bax and the apoptosis marker caspase-3 in the tissues surrounding the area of injury was signi...

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Autores principales: Xu, Shaonian, Liu, Jiachuan, Zhang, Yongming, Wang, Chunlin, Wang, Jinbiao, Yang, Yanyan, Huo, Jian, Sun, Wenjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research and Report: Peripheral Nerve Injury and Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308802/
https://www.ncbi.nlm.nih.gov/pubmed/25657662
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.17.006
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author Xu, Shaonian
Liu, Jiachuan
Zhang, Yongming
Wang, Chunlin
Wang, Jinbiao
Yang, Yanyan
Huo, Jian
Sun, Wenjiang
author_facet Xu, Shaonian
Liu, Jiachuan
Zhang, Yongming
Wang, Chunlin
Wang, Jinbiao
Yang, Yanyan
Huo, Jian
Sun, Wenjiang
author_sort Xu, Shaonian
collection PubMed
description We treated detonator-explosion-induced craniocerebral injury in rabbits with hyperbaric oxygen 1-24 hours post-injury. Expression of the apoptosis-regulating protein cytochrome c, the pro-apoptotic protein Bax and the apoptosis marker caspase-3 in the tissues surrounding the area of injury was significantly reduced, while that of the anti-apoptotic protein Bcl-2 was significantly increased. Our findings indicate that the curative effects of early hyperbaric oxygen on cortical cell apoptosis is associated with suppression of cytochrome c release from mitochondria. This mechanism underlies the observed reduction in Bax expression and upregulation of Bcl-2 expression.
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spelling pubmed-43088022015-02-05 Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy★ Xu, Shaonian Liu, Jiachuan Zhang, Yongming Wang, Chunlin Wang, Jinbiao Yang, Yanyan Huo, Jian Sun, Wenjiang Neural Regen Res Research and Report: Peripheral Nerve Injury and Neural Regeneration We treated detonator-explosion-induced craniocerebral injury in rabbits with hyperbaric oxygen 1-24 hours post-injury. Expression of the apoptosis-regulating protein cytochrome c, the pro-apoptotic protein Bax and the apoptosis marker caspase-3 in the tissues surrounding the area of injury was significantly reduced, while that of the anti-apoptotic protein Bcl-2 was significantly increased. Our findings indicate that the curative effects of early hyperbaric oxygen on cortical cell apoptosis is associated with suppression of cytochrome c release from mitochondria. This mechanism underlies the observed reduction in Bax expression and upregulation of Bcl-2 expression. Medknow Publications & Media Pvt Ltd 2012-06-15 /pmc/articles/PMC4308802/ /pubmed/25657662 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.17.006 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report: Peripheral Nerve Injury and Neural Regeneration
Xu, Shaonian
Liu, Jiachuan
Zhang, Yongming
Wang, Chunlin
Wang, Jinbiao
Yang, Yanyan
Huo, Jian
Sun, Wenjiang
Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy★
title Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy★
title_full Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy★
title_fullStr Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy★
title_full_unstemmed Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy★
title_short Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy★
title_sort apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy★
topic Research and Report: Peripheral Nerve Injury and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308802/
https://www.ncbi.nlm.nih.gov/pubmed/25657662
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.17.006
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