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Antinociceptive effects of lacosamide on spinal neuronal and behavioural measures of pain in a rat model of osteoarthritis

INTRODUCTION: Alterations in voltage-gated sodium channel (VGSC) function have been linked to chronic pain and are good targets for analgesics. Lacosamide (LCM) is a novel anticonvulsant that enhances the slow inactivation state of VGSCs. This conformational state can be induced by repeated neuronal...

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Detalles Bibliográficos
Autores principales:	Rahman, Wahida, Dickenson, Anthony H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308925/ https://www.ncbi.nlm.nih.gov/pubmed/25533381 http://dx.doi.org/10.1186/s13075-014-0509-x

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