Cargando…

Protective effect of a hydroethanolic extract from Bowdichia virgilioides on muscular damage and oxidative stress caused by strenuous resistance training in rats

BACKGROUND: Natural antioxidants can reduce oxidative damage caused by high-intensity resistance training (RT). We investigated the in vitro antioxidant potential of hydroethanolic extract (HEE) from Bowdichia virgilioides on muscular damage and oxidative stress in rats subjected to high-intensity R...

Descripción completa

Detalles Bibliográficos
Autores principales: dos Santos, Jymmys Lopes, Dantas, Rafaela Eugênia Arce, Lima, Clésio Andrade, de Araújo, Silvan Silva, de Almeida, Elis Cristiane Valença, Marçal, Anderson Carlos, Estevam, Charles dos Santos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308926/
https://www.ncbi.nlm.nih.gov/pubmed/25649187
http://dx.doi.org/10.1186/s12970-014-0058-3
_version_ 1782354611421577216
author dos Santos, Jymmys Lopes
Dantas, Rafaela Eugênia Arce
Lima, Clésio Andrade
de Araújo, Silvan Silva
de Almeida, Elis Cristiane Valença
Marçal, Anderson Carlos
Estevam, Charles dos Santos
author_facet dos Santos, Jymmys Lopes
Dantas, Rafaela Eugênia Arce
Lima, Clésio Andrade
de Araújo, Silvan Silva
de Almeida, Elis Cristiane Valença
Marçal, Anderson Carlos
Estevam, Charles dos Santos
author_sort dos Santos, Jymmys Lopes
collection PubMed
description BACKGROUND: Natural antioxidants can reduce oxidative damage caused by high-intensity resistance training (RT). We investigated the in vitro antioxidant potential of hydroethanolic extract (HEE) from Bowdichia virgilioides on muscular damage and oxidative stress in rats subjected to high-intensity RT. METHODS: Thirty-two male Wistar rats were divided into four experimental groups: 1) control group (CG), oral administration (P.O.) of vehicle; 2) trained group (TG), vehicle-treated with RT; 3) B. virgilioides untrained group (BVG), treated with B. virgilioides HEE (200 mg/kg P.O.); and 4) trained B. virgilioides group (TBVG), treated with B. virgiliodes HEE (200 mg/kg P.O.). All animals were habituated to the training apparatus for 1 week. CT and TBVG animals were subjected to the training protocol, which consisted of three sets of 10 repetitions with 75% of the load established using the one-repetition maximum, for four weeks. CG and BVG animals were manipulated and fixed to the apparatus three times a week with no load. Treatment with B. virgilioides HEE or vehicle treatment was initiated after 25 days of RT (5 days; one dose per day). At the end of the experiments, plasmatic and gastrocnemius samples from all groups were obtained for the assessment of lipid peroxidation and creatine kinase activity. RESULTS: Compared to TG rats, TBVG rats showed decreases in plasma and gastrocnemius tissue lipid peroxidation by 55.68% (p <0.0001) and 66.61% (p <0.0012), respectively. Further, compared to TG rats TBVG rats showed decreases in plasma and gastrocnemius tissue oxidative stress by 62.83% (p <0.0005) and 54.97% (p <0.0197), respectively. CONCLUSIONS: B. virgilioides HEE treatment reduced markers of oxidative stress caused by high-intensity RT. Further, HEE treatment during training significantly reduced the markers of tissue damage.
format Online
Article
Text
id pubmed-4308926
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-43089262015-02-03 Protective effect of a hydroethanolic extract from Bowdichia virgilioides on muscular damage and oxidative stress caused by strenuous resistance training in rats dos Santos, Jymmys Lopes Dantas, Rafaela Eugênia Arce Lima, Clésio Andrade de Araújo, Silvan Silva de Almeida, Elis Cristiane Valença Marçal, Anderson Carlos Estevam, Charles dos Santos J Int Soc Sports Nutr Research Article BACKGROUND: Natural antioxidants can reduce oxidative damage caused by high-intensity resistance training (RT). We investigated the in vitro antioxidant potential of hydroethanolic extract (HEE) from Bowdichia virgilioides on muscular damage and oxidative stress in rats subjected to high-intensity RT. METHODS: Thirty-two male Wistar rats were divided into four experimental groups: 1) control group (CG), oral administration (P.O.) of vehicle; 2) trained group (TG), vehicle-treated with RT; 3) B. virgilioides untrained group (BVG), treated with B. virgilioides HEE (200 mg/kg P.O.); and 4) trained B. virgilioides group (TBVG), treated with B. virgiliodes HEE (200 mg/kg P.O.). All animals were habituated to the training apparatus for 1 week. CT and TBVG animals were subjected to the training protocol, which consisted of three sets of 10 repetitions with 75% of the load established using the one-repetition maximum, for four weeks. CG and BVG animals were manipulated and fixed to the apparatus three times a week with no load. Treatment with B. virgilioides HEE or vehicle treatment was initiated after 25 days of RT (5 days; one dose per day). At the end of the experiments, plasmatic and gastrocnemius samples from all groups were obtained for the assessment of lipid peroxidation and creatine kinase activity. RESULTS: Compared to TG rats, TBVG rats showed decreases in plasma and gastrocnemius tissue lipid peroxidation by 55.68% (p <0.0001) and 66.61% (p <0.0012), respectively. Further, compared to TG rats TBVG rats showed decreases in plasma and gastrocnemius tissue oxidative stress by 62.83% (p <0.0005) and 54.97% (p <0.0197), respectively. CONCLUSIONS: B. virgilioides HEE treatment reduced markers of oxidative stress caused by high-intensity RT. Further, HEE treatment during training significantly reduced the markers of tissue damage. BioMed Central 2014-12-24 /pmc/articles/PMC4308926/ /pubmed/25649187 http://dx.doi.org/10.1186/s12970-014-0058-3 Text en © dos Santos et al.; licensee BioMed Central. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
dos Santos, Jymmys Lopes
Dantas, Rafaela Eugênia Arce
Lima, Clésio Andrade
de Araújo, Silvan Silva
de Almeida, Elis Cristiane Valença
Marçal, Anderson Carlos
Estevam, Charles dos Santos
Protective effect of a hydroethanolic extract from Bowdichia virgilioides on muscular damage and oxidative stress caused by strenuous resistance training in rats
title Protective effect of a hydroethanolic extract from Bowdichia virgilioides on muscular damage and oxidative stress caused by strenuous resistance training in rats
title_full Protective effect of a hydroethanolic extract from Bowdichia virgilioides on muscular damage and oxidative stress caused by strenuous resistance training in rats
title_fullStr Protective effect of a hydroethanolic extract from Bowdichia virgilioides on muscular damage and oxidative stress caused by strenuous resistance training in rats
title_full_unstemmed Protective effect of a hydroethanolic extract from Bowdichia virgilioides on muscular damage and oxidative stress caused by strenuous resistance training in rats
title_short Protective effect of a hydroethanolic extract from Bowdichia virgilioides on muscular damage and oxidative stress caused by strenuous resistance training in rats
title_sort protective effect of a hydroethanolic extract from bowdichia virgilioides on muscular damage and oxidative stress caused by strenuous resistance training in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308926/
https://www.ncbi.nlm.nih.gov/pubmed/25649187
http://dx.doi.org/10.1186/s12970-014-0058-3
work_keys_str_mv AT dossantosjymmyslopes protectiveeffectofahydroethanolicextractfrombowdichiavirgilioidesonmusculardamageandoxidativestresscausedbystrenuousresistancetraininginrats
AT dantasrafaelaeugeniaarce protectiveeffectofahydroethanolicextractfrombowdichiavirgilioidesonmusculardamageandoxidativestresscausedbystrenuousresistancetraininginrats
AT limaclesioandrade protectiveeffectofahydroethanolicextractfrombowdichiavirgilioidesonmusculardamageandoxidativestresscausedbystrenuousresistancetraininginrats
AT dearaujosilvansilva protectiveeffectofahydroethanolicextractfrombowdichiavirgilioidesonmusculardamageandoxidativestresscausedbystrenuousresistancetraininginrats
AT dealmeidaeliscristianevalenca protectiveeffectofahydroethanolicextractfrombowdichiavirgilioidesonmusculardamageandoxidativestresscausedbystrenuousresistancetraininginrats
AT marcalandersoncarlos protectiveeffectofahydroethanolicextractfrombowdichiavirgilioidesonmusculardamageandoxidativestresscausedbystrenuousresistancetraininginrats
AT estevamcharlesdossantos protectiveeffectofahydroethanolicextractfrombowdichiavirgilioidesonmusculardamageandoxidativestresscausedbystrenuousresistancetraininginrats