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Protein Changes Contributing to Right Ventricular Cardiomyocyte Diastolic Dysfunction in Pulmonary Arterial Hypertension

BACKGROUND: Right ventricular (RV) diastolic function is impaired in patients with pulmonary arterial hypertension (PAH). Our previous study showed that elevated cardiomyocyte stiffness and myofilament Ca(2+) sensitivity underlie diastolic dysfunction in PAH. This study investigates protein modifica...

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Detalles Bibliográficos
Autores principales:	Rain, Silvia, Bos, Denielli da Silva Goncalves, Handoko, M. Louis, Westerhof, Nico, Stienen, Ger, Ottenheijm, Coen, Goebel, Max, Dorfmüller, Peter, Guignabert, Christophe, Humbert, Marc, Bogaard, Harm‐Jan, dos Remedios, Cris, Saripalli, Chandra, Hidalgo, Carlos G., Granzier, Henk L., Vonk‐Noordegraaf, Anton, van der Velden, Jolanda, de Man, Frances S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309054/ https://www.ncbi.nlm.nih.gov/pubmed/24895160 http://dx.doi.org/10.1161/JAHA.113.000716

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