Vulnerability of the Developing Heart to Oxygen Deprivation as a Cause of Congenital Heart Defects

BACKGROUND: The heart develops under reduced and varying oxygen concentrations, yet there is little understanding of oxygen metabolism in the normal and mal‐development of the heart. Here we used a novel reagent, the ODD‐Luc hypoxia reporter mouse (oxygen degradation domain, ODD) of Hif‐1α fused to...

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Detalles Bibliográficos
Autores principales: Kenchegowda, Doreswamy, Liu, Hongbin, Thompson, Keyata, Luo, Liping, Martin, Stuart S., Fisher, Steven A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309110/
https://www.ncbi.nlm.nih.gov/pubmed/24855117
http://dx.doi.org/10.1161/JAHA.114.000841

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