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Adipose-Derived Stem Cells in Radiotherapy Injury: A New Frontier
Radiotherapy is increasingly used to treat numerous human malignancies. In addition to the beneficial anti-cancer effects, there are a series of undesirable effects on normal host tissues surrounding the target tumor. While the early effects of radiotherapy (desquamation, erythema, and hair loss) ty...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309196/ https://www.ncbi.nlm.nih.gov/pubmed/25674565 http://dx.doi.org/10.3389/fsurg.2015.00001 |
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author | Shukla, Lipi Morrison, Wayne A. Shayan, Ramin |
author_facet | Shukla, Lipi Morrison, Wayne A. Shayan, Ramin |
author_sort | Shukla, Lipi |
collection | PubMed |
description | Radiotherapy is increasingly used to treat numerous human malignancies. In addition to the beneficial anti-cancer effects, there are a series of undesirable effects on normal host tissues surrounding the target tumor. While the early effects of radiotherapy (desquamation, erythema, and hair loss) typically resolve, the chronic effects persist as unpredictable and often troublesome sequelae of cancer treatment, long after oncological treatment has been completed. Plastic surgeons are often called upon to treat the problems subsequently arising in irradiated tissues, such as recurrent infection, impaired healing, fibrosis, contracture, and/or lymphedema. Recently, it was anecdotally noted – then validated in more robust animal and human studies – that fat grafting can ameliorate some of these chronic tissue effects. Despite the widespread usage of fat grafting, the mechanism of its action remains poorly understood. This review provides an overview of the current understanding of: (i) mechanisms of chronic radiation injury and its clinical manifestations; (ii) biological properties of fat grafts and their key constituent, adipose-derived stem cells (ADSCs); and (iii) the role of ADSCs in radiotherapy-induced soft-tissue injury. |
format | Online Article Text |
id | pubmed-4309196 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-43091962015-02-11 Adipose-Derived Stem Cells in Radiotherapy Injury: A New Frontier Shukla, Lipi Morrison, Wayne A. Shayan, Ramin Front Surg Surgery Radiotherapy is increasingly used to treat numerous human malignancies. In addition to the beneficial anti-cancer effects, there are a series of undesirable effects on normal host tissues surrounding the target tumor. While the early effects of radiotherapy (desquamation, erythema, and hair loss) typically resolve, the chronic effects persist as unpredictable and often troublesome sequelae of cancer treatment, long after oncological treatment has been completed. Plastic surgeons are often called upon to treat the problems subsequently arising in irradiated tissues, such as recurrent infection, impaired healing, fibrosis, contracture, and/or lymphedema. Recently, it was anecdotally noted – then validated in more robust animal and human studies – that fat grafting can ameliorate some of these chronic tissue effects. Despite the widespread usage of fat grafting, the mechanism of its action remains poorly understood. This review provides an overview of the current understanding of: (i) mechanisms of chronic radiation injury and its clinical manifestations; (ii) biological properties of fat grafts and their key constituent, adipose-derived stem cells (ADSCs); and (iii) the role of ADSCs in radiotherapy-induced soft-tissue injury. Frontiers Media S.A. 2015-01-28 /pmc/articles/PMC4309196/ /pubmed/25674565 http://dx.doi.org/10.3389/fsurg.2015.00001 Text en Copyright © 2015 Shukla, Morrison and Shayan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Surgery Shukla, Lipi Morrison, Wayne A. Shayan, Ramin Adipose-Derived Stem Cells in Radiotherapy Injury: A New Frontier |
title | Adipose-Derived Stem Cells in Radiotherapy Injury: A New Frontier |
title_full | Adipose-Derived Stem Cells in Radiotherapy Injury: A New Frontier |
title_fullStr | Adipose-Derived Stem Cells in Radiotherapy Injury: A New Frontier |
title_full_unstemmed | Adipose-Derived Stem Cells in Radiotherapy Injury: A New Frontier |
title_short | Adipose-Derived Stem Cells in Radiotherapy Injury: A New Frontier |
title_sort | adipose-derived stem cells in radiotherapy injury: a new frontier |
topic | Surgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309196/ https://www.ncbi.nlm.nih.gov/pubmed/25674565 http://dx.doi.org/10.3389/fsurg.2015.00001 |
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