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Notch3/Jagged1 Circuitry Reinforces Notch Signaling and Sustains T-ALL()()

Deregulated Notch signaling has been extensively linked to T-cell acute lymphoblastic leukemia (T-ALL). Here, we show a direct relationship between Notch3 receptor and Jagged1 ligand in human cell lines and in a mouse model of T-ALL. We provide evidence that Notch-specific ligand Jagged1 is a new No...

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Detalles Bibliográficos
Autores principales:	Pelullo, Maria, Quaranta, Roberta, Talora, Claudio, Checquolo, Saula, Cialfi, Samantha, Felli, Maria Pia, te Kronnie, Geertruy, Borga, Chiara, Besharat, Zein Mersini, Palermo, Rocco, Di Marcotullio, Lucia, Capobianco, Anthony J., Gulino, Alberto, Screpanti, Isabella, Bellavia, Diana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309263/ https://www.ncbi.nlm.nih.gov/pubmed/25499214 http://dx.doi.org/10.1016/j.neo.2014.10.004

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