Cargando…

Alendronate and Raloxifene Therapy in the Early Period after Hip Fracture

Objective: The purpose of the present study was to clarify the efficacy of alendronate and raloxifene for preventing bone loss in patients with hip fracture by monitoring bone mineral densities (BMDs) and biochemical markers during the 9-month period after fracture. Patients and Methods: Eighty-two...

Descripción completa

Detalles Bibliográficos
Autores principales: Ohishi, Tsuyoshi, Ichikawa, Tetsuya, Ito, Takanori, Koyama, Hiroshi, Miyagi, Michihito, Hoshino, Hironobu, Takahashi, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Association of Rural Medicine 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309344/
https://www.ncbi.nlm.nih.gov/pubmed/25650026
http://dx.doi.org/10.2185/jrm.6.16
_version_ 1782354678781050880
author Ohishi, Tsuyoshi
Ichikawa, Tetsuya
Ito, Takanori
Koyama, Hiroshi
Miyagi, Michihito
Hoshino, Hironobu
Takahashi, Masaaki
author_facet Ohishi, Tsuyoshi
Ichikawa, Tetsuya
Ito, Takanori
Koyama, Hiroshi
Miyagi, Michihito
Hoshino, Hironobu
Takahashi, Masaaki
author_sort Ohishi, Tsuyoshi
collection PubMed
description Objective: The purpose of the present study was to clarify the efficacy of alendronate and raloxifene for preventing bone loss in patients with hip fracture by monitoring bone mineral densities (BMDs) and biochemical markers during the 9-month period after fracture. Patients and Methods: Eighty-two female hip fracture patients from 50 to 99 years old (mean ± SD: 81.6 ± 9.5) were randomly divided into two groups; there were 46 patients in the alendronate-treated group (group ALN) and 36 patients in the raloxifene-treated group (group RLX). Drugs were administered to patients six weeks after their operations. Lumbar spine BMD and neck, trochanter, Ward’s and total BMDs of the contralateral proximal femur, serum intact osteocalcin (intact OC), bone-specific alkaline phosphatase (BAP) and urinary N-terminal telopeptide of type I collagen (NTX) were measured just before the start of drug administration and at 9 months thereafter. Results: Twenty-two out of 46 patients in group ALN and 23 out of 36 patients in group RLX completed the study. The most common reason for dropping out was the patient’s failure to visit the outpatient clinic. Trochanter BMD in group ALN tended to increase by 8.4% compared with the baseline, and total hip BMD in group RLX showed a significant increase (5.7%), although neck BMD in both groups decreased during the 9 months of treatment (−8.7% for group ALN and −4.2% for group RLX compared with the baseline). Spine BMD did not change significantly in eithr group. Serum BAP and urinary NTX decreased significantly in both groups. Serum intact OC did not change significantly. Conclusions: Both alendronate and raloxifene have a favorable effect on trochanter and total BMDs of the contralateral proximal femur in the short period after hip fracture. However, both drugs could not prevent bone loss in the femoral neck during the 9 months of treatment.
format Online
Article
Text
id pubmed-4309344
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher The Japanese Association of Rural Medicine
record_format MEDLINE/PubMed
spelling pubmed-43093442015-02-03 Alendronate and Raloxifene Therapy in the Early Period after Hip Fracture Ohishi, Tsuyoshi Ichikawa, Tetsuya Ito, Takanori Koyama, Hiroshi Miyagi, Michihito Hoshino, Hironobu Takahashi, Masaaki J Rural Med Original Article Objective: The purpose of the present study was to clarify the efficacy of alendronate and raloxifene for preventing bone loss in patients with hip fracture by monitoring bone mineral densities (BMDs) and biochemical markers during the 9-month period after fracture. Patients and Methods: Eighty-two female hip fracture patients from 50 to 99 years old (mean ± SD: 81.6 ± 9.5) were randomly divided into two groups; there were 46 patients in the alendronate-treated group (group ALN) and 36 patients in the raloxifene-treated group (group RLX). Drugs were administered to patients six weeks after their operations. Lumbar spine BMD and neck, trochanter, Ward’s and total BMDs of the contralateral proximal femur, serum intact osteocalcin (intact OC), bone-specific alkaline phosphatase (BAP) and urinary N-terminal telopeptide of type I collagen (NTX) were measured just before the start of drug administration and at 9 months thereafter. Results: Twenty-two out of 46 patients in group ALN and 23 out of 36 patients in group RLX completed the study. The most common reason for dropping out was the patient’s failure to visit the outpatient clinic. Trochanter BMD in group ALN tended to increase by 8.4% compared with the baseline, and total hip BMD in group RLX showed a significant increase (5.7%), although neck BMD in both groups decreased during the 9 months of treatment (−8.7% for group ALN and −4.2% for group RLX compared with the baseline). Spine BMD did not change significantly in eithr group. Serum BAP and urinary NTX decreased significantly in both groups. Serum intact OC did not change significantly. Conclusions: Both alendronate and raloxifene have a favorable effect on trochanter and total BMDs of the contralateral proximal femur in the short period after hip fracture. However, both drugs could not prevent bone loss in the femoral neck during the 9 months of treatment. The Japanese Association of Rural Medicine 2011-07-15 2011 /pmc/articles/PMC4309344/ /pubmed/25650026 http://dx.doi.org/10.2185/jrm.6.16 Text en ©2011 The Japanese Association of Rural Medicine http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Original Article
Ohishi, Tsuyoshi
Ichikawa, Tetsuya
Ito, Takanori
Koyama, Hiroshi
Miyagi, Michihito
Hoshino, Hironobu
Takahashi, Masaaki
Alendronate and Raloxifene Therapy in the Early Period after Hip Fracture
title Alendronate and Raloxifene Therapy in the Early Period after Hip Fracture
title_full Alendronate and Raloxifene Therapy in the Early Period after Hip Fracture
title_fullStr Alendronate and Raloxifene Therapy in the Early Period after Hip Fracture
title_full_unstemmed Alendronate and Raloxifene Therapy in the Early Period after Hip Fracture
title_short Alendronate and Raloxifene Therapy in the Early Period after Hip Fracture
title_sort alendronate and raloxifene therapy in the early period after hip fracture
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309344/
https://www.ncbi.nlm.nih.gov/pubmed/25650026
http://dx.doi.org/10.2185/jrm.6.16
work_keys_str_mv AT ohishitsuyoshi alendronateandraloxifenetherapyintheearlyperiodafterhipfracture
AT ichikawatetsuya alendronateandraloxifenetherapyintheearlyperiodafterhipfracture
AT itotakanori alendronateandraloxifenetherapyintheearlyperiodafterhipfracture
AT koyamahiroshi alendronateandraloxifenetherapyintheearlyperiodafterhipfracture
AT miyagimichihito alendronateandraloxifenetherapyintheearlyperiodafterhipfracture
AT hoshinohironobu alendronateandraloxifenetherapyintheearlyperiodafterhipfracture
AT takahashimasaaki alendronateandraloxifenetherapyintheearlyperiodafterhipfracture