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Metabolome-genome-wide association study dissects genetic architecture for generating natural variation in rice secondary metabolism
Plants produce structurally diverse secondary (specialized) metabolites to increase their fitness for survival under adverse environments. Several bioactive compounds for new drugs have been identified through screening of plant extracts. In this study, genome-wide association studies (GWAS) were co...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309412/ https://www.ncbi.nlm.nih.gov/pubmed/25267402 http://dx.doi.org/10.1111/tpj.12681 |
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author | Matsuda, Fumio Nakabayashi, Ryo Yang, Zhigang Okazaki, Yozo Yonemaru, Jun-ichi Ebana, Kaworu Yano, Masahiro Saito, Kazuki |
author_facet | Matsuda, Fumio Nakabayashi, Ryo Yang, Zhigang Okazaki, Yozo Yonemaru, Jun-ichi Ebana, Kaworu Yano, Masahiro Saito, Kazuki |
author_sort | Matsuda, Fumio |
collection | PubMed |
description | Plants produce structurally diverse secondary (specialized) metabolites to increase their fitness for survival under adverse environments. Several bioactive compounds for new drugs have been identified through screening of plant extracts. In this study, genome-wide association studies (GWAS) were conducted to investigate the genetic architecture behind the natural variation of rice secondary metabolites. GWAS using the metabolome data of 175 rice accessions successfully identified 323 associations among 143 single nucleotide polymorphisms (SNPs) and 89 metabolites. The data analysis highlighted that levels of many metabolites are tightly associated with a small number of strong quantitative trait loci (QTLs). The tight association may be a mechanism generating strains with distinct metabolic composition through the crossing of two different strains. The results indicate that one plant species produces more diverse phytochemicals than previously expected, and plants still contain many useful compounds for human applications. |
format | Online Article Text |
id | pubmed-4309412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43094122015-02-09 Metabolome-genome-wide association study dissects genetic architecture for generating natural variation in rice secondary metabolism Matsuda, Fumio Nakabayashi, Ryo Yang, Zhigang Okazaki, Yozo Yonemaru, Jun-ichi Ebana, Kaworu Yano, Masahiro Saito, Kazuki Plant J Original Articles Plants produce structurally diverse secondary (specialized) metabolites to increase their fitness for survival under adverse environments. Several bioactive compounds for new drugs have been identified through screening of plant extracts. In this study, genome-wide association studies (GWAS) were conducted to investigate the genetic architecture behind the natural variation of rice secondary metabolites. GWAS using the metabolome data of 175 rice accessions successfully identified 323 associations among 143 single nucleotide polymorphisms (SNPs) and 89 metabolites. The data analysis highlighted that levels of many metabolites are tightly associated with a small number of strong quantitative trait loci (QTLs). The tight association may be a mechanism generating strains with distinct metabolic composition through the crossing of two different strains. The results indicate that one plant species produces more diverse phytochemicals than previously expected, and plants still contain many useful compounds for human applications. Blackwell Publishing Ltd 2015-01 2014-09-29 /pmc/articles/PMC4309412/ /pubmed/25267402 http://dx.doi.org/10.1111/tpj.12681 Text en © 2014 The Authors The Plant Journal published by Society for Experimental Biology and John Wiley & Sons Ltd. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Matsuda, Fumio Nakabayashi, Ryo Yang, Zhigang Okazaki, Yozo Yonemaru, Jun-ichi Ebana, Kaworu Yano, Masahiro Saito, Kazuki Metabolome-genome-wide association study dissects genetic architecture for generating natural variation in rice secondary metabolism |
title | Metabolome-genome-wide association study dissects genetic architecture for generating natural variation in rice secondary metabolism |
title_full | Metabolome-genome-wide association study dissects genetic architecture for generating natural variation in rice secondary metabolism |
title_fullStr | Metabolome-genome-wide association study dissects genetic architecture for generating natural variation in rice secondary metabolism |
title_full_unstemmed | Metabolome-genome-wide association study dissects genetic architecture for generating natural variation in rice secondary metabolism |
title_short | Metabolome-genome-wide association study dissects genetic architecture for generating natural variation in rice secondary metabolism |
title_sort | metabolome-genome-wide association study dissects genetic architecture for generating natural variation in rice secondary metabolism |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309412/ https://www.ncbi.nlm.nih.gov/pubmed/25267402 http://dx.doi.org/10.1111/tpj.12681 |
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