The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates

Ubiquitin is known to be one of the most soluble and stably folded intracellular proteins, but it is often found in inclusion bodies associated with various diseases including neurodegenerative disorders and cancer. To gain insight into this contradictory behaviour, we have examined the physicochemi...

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Detalles Bibliográficos
Autores principales: Morimoto, Daichi, Walinda, Erik, Fukada, Harumi, Sou, Yu-Shin, Kageyama, Shun, Hoshino, Masaru, Fujii, Takashi, Tsuchiya, Hikaru, Saeki, Yasushi, Arita, Kyohei, Ariyoshi, Mariko, Tochio, Hidehito, Iwai, Kazuhiro, Namba, Keiichi, Komatsu, Masaaki, Tanaka, Keiji, Shirakawa, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309437/
https://www.ncbi.nlm.nih.gov/pubmed/25600778
http://dx.doi.org/10.1038/ncomms7116

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