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Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma

Common variants at many loci have been robustly associated with asthma but explain little of the overall genetic risk. Here we investigate the role of rare (<1%) and low-frequency (1–5%) variants using the Illumina HumanExome BeadChip array in 4,794 asthma cases, 4,707 non-asthmatic controls and...

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Detalles Bibliográficos
Autores principales: Igartua, Catherine, Myers, Rachel A., Mathias, Rasika A., Pino-Yanes, Maria, Eng, Celeste, Graves, Penelope E., Levin, Albert M., Del-Rio-Navarro, Blanca E., Jackson, Daniel J., Livne, Oren E., Rafaels, Nicholas, Edlund, Christopher K., Yang, James J., Huntsman, Scott, Salam, Muhammad T., Romieu, Isabelle, Mourad, Raphael, Gern, James E., Lemanske, Robert F., Wyss, Annah, Hoppin, Jane A., Barnes, Kathleen C., Burchard, Esteban G., Gauderman, W. James, Martinez, Fernando D., Raby, Benjamin A., Weiss, Scott T., Williams, L. Keoki, London, Stephanie J., Gilliland, Frank D., Nicolae, Dan L., Ober, Carole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309441/
https://www.ncbi.nlm.nih.gov/pubmed/25591454
http://dx.doi.org/10.1038/ncomms6965

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