Cargando…

The Resveratrol Trimer Miyabenol C Inhibits β-Secretase Activity and β-Amyloid Generation

Accumulation and deposition of amyloid-β peptide (Aβ) in the brain is a primary cause of the pathogenesis of Alzheimer’s disease (AD). Aβ is generated from amyloid-β precursor protein (APP) through sequential cleavages first by β-secretase and then by γ-secretase. Inhibiting β-secretase activity is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Jin, Lin, Ting, Gao, Yuehong, Xu, Junyue, Jiang, Chao, Wang, Guanghui, Bu, Guojun, Xu, Huaxi, Chen, Haifeng, Zhang, Yun-wu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309453/ https://www.ncbi.nlm.nih.gov/pubmed/25629409 http://dx.doi.org/10.1371/journal.pone.0115973

Ejemplares similares

Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer’s disease-related pathogenesis
por: Cui, Jin, et al.
Publicado: (2015)

Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase
por: Steiner, Harald, et al.
Publicado: (2018)

A lipid boundary separates APP and secretases and limits amyloid β-peptide generation
por: Kaether, Christoph, et al.
Publicado: (2004)

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation†
por: Zhou, Lujia, et al.
Publicado: (2011)

Interplay between α-, β-, and γ-Secretases Determines Biphasic Amyloid-β Protein Level in the Presence of a γ-Secretase Inhibitor
por: Ortega, Fernando, et al.
Publicado: (2013)

Atomistic investigation of an Iowa Amyloid-β trimer in aqueous solution
por: Ngo, Son Tung, et al.
Publicado: (2018)

Substrate interaction inhibits γ-secretase production of amyloid-β peptides
por: Zhao, Jing, et al.
Publicado: (2020)

β-Arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology
por: Liu, Xiaosong, et al.
Publicado: (2013)

α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP
por: Roberts, Hazel L., et al.
Publicado: (2017)

Partial reduction of amyloid β production by β-secretase inhibitors does not decrease synaptic transmission
por: Satir, Tugce Munise, et al.
Publicado: (2020)

Emergence of Barrel Motif in Amyloid-β Trimer: A Computational Study
por: Nguyen, Hoang Linh, et al.
Publicado: (2020)

Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: analysis with a palmitoylation-deficient mutant
por: Motoki, Kazumi, et al.
Publicado: (2012)

Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio
por: Xu, Ting-Hai, et al.
Publicado: (2016)

The γ-secretase complex: from structure to function
por: Zhang, Xian, et al.
Publicado: (2014)

The biological function of β-secretase
por: Haass, Christian
Publicado: (2013)

ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production
por: Sano, Osamu, et al.
Publicado: (2016)

Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol
por: Rudajev, Vladimir, et al.
Publicado: (2023)

The Metalloprotease Meprin β Is an Alternative β-Secretase of APP
por: Becker-Pauly, Christoph, et al.
Publicado: (2017)

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer’s disease
por: Thathiah, Amantha, et al.
Publicado: (2013)

Astrocytes infected with Chlamydia pneumoniae demonstrate altered expression and activity of secretases involved in the generation of β-amyloid found in Alzheimer disease
por: Al-Atrache, Zein, et al.
Publicado: (2019)

The emerging role of β-secretases in cancer
por: Farris, Francesco, et al.
Publicado: (2021)

Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase
por: Scholefield, Zoe, et al.
Publicado: (2003)

Increased γ-Secretase Activity in Idiopathic Normal Pressure Hydrocephalus Patients with β-Amyloid Pathology
por: Laiterä, Tiina, et al.
Publicado: (2014)

Divalent cation tolerance protein binds to β-secretase and inhibits the processing of amyloid precursor protein☆
por: Liu, Runzhong, et al.
Publicado: (2013)

Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells
por: Chyung, Abraham S.C., et al.
Publicado: (1997)

Biochemical Inhibition of the Acetyltransferases ATase1 and ATase2 Reduces β-Secretase (BACE1) Levels and Aβ Generation
por: Ding, Yun, et al.
Publicado: (2012)

Specific Mutations near the Amyloid Precursor Protein Cleavage Site Increase γ-Secretase Sensitivity and Modulate Amyloid-β Production
por: Suzuki, Ryota, et al.
Publicado: (2023)

Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β(42/40) Ratio
por: Uemura, Kengo, et al.
Publicado: (2009)

Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase
por: Morishima-Kawashima, Maho
Publicado: (2014)

ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity
por: Zhu, Bing, et al.
Publicado: (2017)

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease
por: Kanekiyo, Takahisa, et al.
Publicado: (2014)

LRP1 plays a major role in the amyloid-β clearance in microglia
por: N’Songo, Aurelie, et al.
Publicado: (2013)

A New Resveratrol Trimer from the Roots and Stems of Vitis wenchowensis
por: Gu, Binbin, et al.
Publicado: (2013)

β-Secretases, Alzheimer's Disease, and Down Syndrome
por: Webb, Robin L., et al.
Publicado: (2012)

An Anti-Parkinson’s Disease Drug via Targeting Adenosine A(2A) Receptor Enhances Amyloid-β Generation and γ-Secretase Activity
por: Lu, Jing, et al.
Publicado: (2016)

Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
por: Cam, Judy A, et al.
Publicado: (2006)

γ-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid β-Protein Production
por: Takami, Mako, et al.
Publicado: (2012)

Familial Alzheimer’s disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues
por: Devkota, Sujan, et al.
Publicado: (2021)

Biomimetic Synthesis of Resveratrol Trimers Catalyzed by Horseradish Peroxidase
por: Zhang, Jian-Qiao, et al.
Publicado: (2017)

Resveratrol Trimers from Seed Cake of Paeonia rockii
por: Liu, Pu, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_kdmbd4jn37j5tpmd9jjec5qb7s