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Plasma free fatty acid levels influence Zn(2+)-dependent histidine-rich glycoprotein–heparin interactions via an allosteric switch on serum albumin

BACKGROUND: Histidine-rich glycoprotein (HRG) regulates coagulation through its ability to bind and neutralize heparins. HRG associates with Zn(2+) to stimulate HRG–heparin complex formation. Under normal conditions, the majority of plasma Zn(2+) associates with human serum albumin (HSA). However, f...

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Detalles Bibliográficos
Autores principales:	Kassaar, O, Schwarz-Linek, U, Blindauer, C A, Stewart, A J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Coagulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309485/ https://www.ncbi.nlm.nih.gov/pubmed/25353308 http://dx.doi.org/10.1111/jth.12771

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