Cargando…

Creating Novel Activated Factor XI Inhibitors through Fragment Based Lead Generation and Structure Aided Drug Design

Activated factor XI (FXIa) inhibitors are anticipated to combine anticoagulant and profibrinolytic effects with a low bleeding risk. This motivated a structure aided fragment based lead generation campaign to create novel FXIa inhibitor leads. A virtual screen, based on docking experiments, was perf...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fjellström, Ola, Akkaya, Sibel, Beisel, Hans-Georg, Eriksson, Per-Olof, Erixon, Karl, Gustafsson, David, Jurva, Ulrik, Kang, Daiwu, Karis, David, Knecht, Wolfgang, Nerme, Viveca, Nilsson, Ingemar, Olsson, Thomas, Redzic, Alma, Roth, Robert, Sandmark, Jenny, Tigerström, Anna, Öster, Linda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309560/ https://www.ncbi.nlm.nih.gov/pubmed/25629509 http://dx.doi.org/10.1371/journal.pone.0113705

Ejemplares similares

ER network dynamics are differentially controlled by myosins XI-K, XI-C, XI-E, XI-I, XI-1, and XI-2
por: Griffing, Lawrence R., et al.
Publicado: (2014)

Corrigendum: ER network dynamics are differentially controlled by myosins XI-K, XI-C, XI-E, XI-I, XI-1, and XI-2
por: Gao, Hong-Bo
Publicado: (2014)

XI% and OMEGA% resonances in XI-Be interactions
por: Rosselet, P
Publicado: (1987)

Observation of $\Xi_b^0 \rightarrow \Xi_c^+ D_s^-$ and $\Xi_b^- \rightarrow \Xi_c^0 D_s^-$ decays
por: Aaij, Roel, et al.
Publicado: (2023)

Transactions on edutainment XI
por: Pan, Zhigeng, et al.
Publicado: (2015)

Inclusive XI0, XI(1530)- and XI(1530)0 production in XI- Be interactions at 116 GeV/c
por: Schneider, O, et al.
Publicado: (1989)

Search for the radiative $\Xi_b^-\to\Xi^-\gamma$ decay
por: Aaij, Roel, et al.
Publicado: (2021)

Work and family: associations with long-term sick-listing in Swedish women – a case-control study
por: Sandmark, Hélène
Publicado: (2007)

Production of $\Xi_{c}^{0}$ and $\Xi_{b}$ in Z decays and lifetime measurement of $\Xi_{b}$
por: Abdallah, J., et al.
Publicado: (2005)

Production of Xi_c^0 and Xi_b in Z decays and lifetime measurement of Xi_b
por: Berntzon, Lisa
Publicado: (2005)

Production of $\Xi^{0}_{c}$ and $\Xi_b$ in Z decays and lifetime measurement of$\Xi_b$
por: Berntzon, L, et al.
Publicado: (2004)

Direct measurement of $\Xi^{-}$ and $\Xi^0$ mean lives
por: Jauneau, L, et al.
Publicado: (1963)

Sum rules for $\xi\xi$ - scattering amplitudes (In Russian)
por: Fil'kov, L V, et al.
Publicado: (1970)

XI% resonances in XI-Be interactions ; 1, diffractive production in the LAMBDA.K- and XI-pi+pi- channels
por: Biagi, S F, et al.
Publicado: (1987)

Evidence for $\Xi_{c}^{0}$ in the exclusive decay channel $\Xi_{c}^{0}\ to \Xi^{-} \pi^{+}$ in DELPHI
por: Leinonen, L, et al.
Publicado: (2001)

$\Xi^{-}$ properties
por: Jauneau, L, et al.
Publicado: (1963)

$\Xi^{-}$ properties
por: Jauneau, L, et al.
Publicado: (1963)

Measurement of the Cross Sections of $\Xi^0_{c}$ and $\Xi^+_{c}$ Baryons and of the Branching-Fraction Ratio BR($\Xi^0_{c} \rightarrow \Xi^-{e}^+\nu_{ e}$)/BR($\Xi^0_{c} \rightarrow \Xi^-\pi^+$) in pp collisions at 13 TeV
por: Acharya, Shreyasi, et al.
Publicado: (2021)

Particle Tracking in Circular Accelerators Using the Exact Hamiltonian in SixTrack
por: Fjellstrom, Mattias
Publicado: (2013)

Delusion-proneness displays comorbidity with traits of autistic-spectrum disorders and ADHD
por: Louzolo, Anaïs, et al.
Publicado: (2017)

Strangeness tracking in the upgraded ALICE detectors: study of $\Xi_b^- \to (\Xi_c^0 \to \Xi^- \pi^+) \pi^-$
por: Bigot, Alexandre Patrick
Publicado: (2021)

Measurements of the $\Xi^0$ lifetime and the $\overline{\Xi^0}/\Xi^0$ flux ratio in a neutral beam
por: Batley, J Richard, et al.
Publicado: (2007)

XI% resonances in XI-Be interactions ; 2, properties of XI(1820) and XI(1960) in the LAMBDA.$\overline{K}$0 and SIGMA0$\overline{K}$0 channels
por: Biagi, S F, et al.
Publicado: (1986)

Observation of the exclusive decays \Xi^0_c -> \Lambda^0 K^0_s and \Xi^0_c -> \Xi^- \pi^+
por: Lesiak, T
Publicado: (1999)

Myosins XI-K, XI-1, and XI-2 are required for development of pavement cells, trichomes, and stigmatic papillae in Arabidopsis
por: Ojangu, Eve-Ly, et al.
Publicado: (2012)

Rivetisation of the cross sections of prompt $\Xi_c^{0}$ and $\Xi_c^{+}$ baryons and the Branching-fraction ratio BR$(\Xi_c^{0}\rightarrow \Xi^{-}e^{+}\nu_{e})/$BR$(\Xi_{c}^{0}\rightarrow \Xi^{-}\pi^{+})$ in pp at $\sqrt{s} = 13$ TeV
por: Lourens, Yonne
Publicado: (2022)

Masses, Lifetimes and Production Rates of \Xi^- and \bar\Xi^+ at LEP1
por: DELPHI Collaboration
Publicado: (2018)

Masses, lifetimes and production rates of $\Xi-$ and $anti\Xi+$ at LEP 1
por: Abdallah, J., et al.
Publicado: (2006)

Understanding long-term sick leave in female white-collar workers with burnout and stress-related diagnoses: a qualitative study
por: Sandmark, Hélène, et al.
Publicado: (2010)

Lewin's genes XI
por: Krebs, Jocelyn E.
Publicado: (2014)

$\Xi^{-}$ Magnetic moment
por: Charpak, G, et al.
Publicado: (1965)

Eurosensors XI Conference
por: Collective
Publicado: (1998)

Adobe Acrobat XI
por: Peachpit
Publicado: (2013)

Mathematics for class XI
por: Khattar, Dinesh, et al.
Publicado: (2004)

The masses of the $\Xi$ hyperons
por: Wilquet, G, et al.
Publicado: (1972)

Chapter XI. Of Blaines
Publicado: (1894)

A simple and robust method to measure Xi(c) and Xi(b) polarizations
por: Faccioli, Pietro, et al.
Publicado: (2011)

First observation of the $\Xi^{-}\pi^{+}$ decay mode of the $\Xi(1690)^{0}$ hyperon
por: Adamovich, M I, et al.
Publicado: (1998)

First observation of the $\Xi^{-} \pi^{+}$ decay mode of the $\Xi^{0}(1690)$ hyperon
por: Adamovich, M.I., et al.
Publicado: (1997)

First measurement of the (XI- --> SIGMA-gamma) / (XI- --> LAMBDA.pi-) branching ratio
por: Biagi, S F, et al.
Publicado: (1987)

Cannot write session to /tmp/vufind_sessions/sess_u6uaq3g2skfam2804f7ip5s4fj