Meta-Analysis of Anti-Muscarinic Receptor Type 3 Antibodies for the Diagnosis of Sjögren Syndrome

PURPOSE: To conduct a meta-analysis to evaluate the diagnostic value of anti-muscarinic receptor type 3 (M3R) antibodies in Sjögren syndrome (SS). METHODS: Two databases, PUBMED and the Cochrane Library, were systematically searched. Approximately 2,000 participants from several studies were include...

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Detalles Bibliográficos
Autores principales: Deng, Chuiwen, Hu, Chaojun, Chen, Si, Li, Jing, Wen, Xiaoting, Wu, Ziyan, Li, Yuan, Zhang, Fengchun, Li, Yongzhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309563/
https://www.ncbi.nlm.nih.gov/pubmed/25629973
http://dx.doi.org/10.1371/journal.pone.0116744
Descripción
Sumario:PURPOSE: To conduct a meta-analysis to evaluate the diagnostic value of anti-muscarinic receptor type 3 (M3R) antibodies in Sjögren syndrome (SS). METHODS: Two databases, PUBMED and the Cochrane Library, were systematically searched. Approximately 2,000 participants from several studies were included in this research. STATA 11.2 software and Meta-DiSc 1.4 was used to conduct the meta-analysis. RESULTS: Eleven studies were included in the meta-analysis. The pooled DOR was 13.00 (95% CI, 6.00–26.00). The sensitivity was 0.43 (95% CI, 0.28–0.58) and the specificity was 0.95 (95%CI, 0.91–0.97). The LR+ and LR- were 7.90 (95% CI, 4.70–13.40), 0.61 (95% CI, 0.46–0.79), respectively. The AUC was 0.89 (95% CI, 0.86–0.92). CONCLUSION: The anti-M3R antibody had high specificity but relatively low sensitivity for the diagnosis of SS.

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