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Murine Pancreatic Adenocarcinoma Reduces Ikaros Expression and Disrupts T Cell Homeostasis

BACKGROUND: Maintenance of T cell immune homeostasis is critical for adequate anti-tumor immunity. The transcription factor Ikaros is essential for lymphocyte development including T cells. Alterations in Ikaros expression occur in blood malignancies in humans and mice. In this study, we investigate...

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Detalles Bibliográficos
Autores principales:	Nelson, Nadine, Xiang, Shengyan, Zhang, Xiaohong, Gilvary, Danielle, Djeu, Julie, Husain, Kazim, Malafa, Mokenge, Vohra, Nasreen, Pilon-Thomas, Shari, Ghansah, Tomar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309586/ https://www.ncbi.nlm.nih.gov/pubmed/25629611 http://dx.doi.org/10.1371/journal.pone.0115546

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