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Evaluation of the Effects of Quercetin on Damaged Salivary Secretion

With the aim of discovering an effective method to treat dry mouth, we analyzed the effects of quercetin on salivary secretion and its mechanism of action. We created a mouse model with impaired salivary secretion by exposure to radiation and found that impaired secretion is suppressed by quercetin...

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Autores principales: Takahashi, Ayako, Inoue, Hiroko, Mishima, Kenji, Ide, Fumio, Nakayama, Ryoko, Hasaka, Ayaka, Ryo, Koufuchi, Ito, Yumi, Sakurai, Takashi, Hasegawa, Yoshinori, Saito, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309588/
https://www.ncbi.nlm.nih.gov/pubmed/25629520
http://dx.doi.org/10.1371/journal.pone.0116008
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author Takahashi, Ayako
Inoue, Hiroko
Mishima, Kenji
Ide, Fumio
Nakayama, Ryoko
Hasaka, Ayaka
Ryo, Koufuchi
Ito, Yumi
Sakurai, Takashi
Hasegawa, Yoshinori
Saito, Ichiro
author_facet Takahashi, Ayako
Inoue, Hiroko
Mishima, Kenji
Ide, Fumio
Nakayama, Ryoko
Hasaka, Ayaka
Ryo, Koufuchi
Ito, Yumi
Sakurai, Takashi
Hasegawa, Yoshinori
Saito, Ichiro
author_sort Takahashi, Ayako
collection PubMed
description With the aim of discovering an effective method to treat dry mouth, we analyzed the effects of quercetin on salivary secretion and its mechanism of action. We created a mouse model with impaired salivary secretion by exposure to radiation and found that impaired secretion is suppressed by quercetin intake. Moreover, secretion levels were enhanced in quercetin-fed normal mice. To elucidate the mechanisms of these effects on salivary secretion, we conducted an analysis using mouse submandibular gland tissues, a human salivary gland epithelial cell line (HSY), and mouse aortic endothelial cells (MAECs). The results showed that quercetin augments aquaporin 5 (AQP5) expression and calcium uptake, and suppresses oxidative stress and inflammatory responses induced by radiation exposure, suggesting that quercetin intake may be an effective method to treat impaired salivary secretion.
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spelling pubmed-43095882015-02-06 Evaluation of the Effects of Quercetin on Damaged Salivary Secretion Takahashi, Ayako Inoue, Hiroko Mishima, Kenji Ide, Fumio Nakayama, Ryoko Hasaka, Ayaka Ryo, Koufuchi Ito, Yumi Sakurai, Takashi Hasegawa, Yoshinori Saito, Ichiro PLoS One Research Article With the aim of discovering an effective method to treat dry mouth, we analyzed the effects of quercetin on salivary secretion and its mechanism of action. We created a mouse model with impaired salivary secretion by exposure to radiation and found that impaired secretion is suppressed by quercetin intake. Moreover, secretion levels were enhanced in quercetin-fed normal mice. To elucidate the mechanisms of these effects on salivary secretion, we conducted an analysis using mouse submandibular gland tissues, a human salivary gland epithelial cell line (HSY), and mouse aortic endothelial cells (MAECs). The results showed that quercetin augments aquaporin 5 (AQP5) expression and calcium uptake, and suppresses oxidative stress and inflammatory responses induced by radiation exposure, suggesting that quercetin intake may be an effective method to treat impaired salivary secretion. Public Library of Science 2015-01-28 /pmc/articles/PMC4309588/ /pubmed/25629520 http://dx.doi.org/10.1371/journal.pone.0116008 Text en © 2015 Takahashi et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Takahashi, Ayako
Inoue, Hiroko
Mishima, Kenji
Ide, Fumio
Nakayama, Ryoko
Hasaka, Ayaka
Ryo, Koufuchi
Ito, Yumi
Sakurai, Takashi
Hasegawa, Yoshinori
Saito, Ichiro
Evaluation of the Effects of Quercetin on Damaged Salivary Secretion
title Evaluation of the Effects of Quercetin on Damaged Salivary Secretion
title_full Evaluation of the Effects of Quercetin on Damaged Salivary Secretion
title_fullStr Evaluation of the Effects of Quercetin on Damaged Salivary Secretion
title_full_unstemmed Evaluation of the Effects of Quercetin on Damaged Salivary Secretion
title_short Evaluation of the Effects of Quercetin on Damaged Salivary Secretion
title_sort evaluation of the effects of quercetin on damaged salivary secretion
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309588/
https://www.ncbi.nlm.nih.gov/pubmed/25629520
http://dx.doi.org/10.1371/journal.pone.0116008
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