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Evaluation of the Effects of Quercetin on Damaged Salivary Secretion
With the aim of discovering an effective method to treat dry mouth, we analyzed the effects of quercetin on salivary secretion and its mechanism of action. We created a mouse model with impaired salivary secretion by exposure to radiation and found that impaired secretion is suppressed by quercetin...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309588/ https://www.ncbi.nlm.nih.gov/pubmed/25629520 http://dx.doi.org/10.1371/journal.pone.0116008 |
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author | Takahashi, Ayako Inoue, Hiroko Mishima, Kenji Ide, Fumio Nakayama, Ryoko Hasaka, Ayaka Ryo, Koufuchi Ito, Yumi Sakurai, Takashi Hasegawa, Yoshinori Saito, Ichiro |
author_facet | Takahashi, Ayako Inoue, Hiroko Mishima, Kenji Ide, Fumio Nakayama, Ryoko Hasaka, Ayaka Ryo, Koufuchi Ito, Yumi Sakurai, Takashi Hasegawa, Yoshinori Saito, Ichiro |
author_sort | Takahashi, Ayako |
collection | PubMed |
description | With the aim of discovering an effective method to treat dry mouth, we analyzed the effects of quercetin on salivary secretion and its mechanism of action. We created a mouse model with impaired salivary secretion by exposure to radiation and found that impaired secretion is suppressed by quercetin intake. Moreover, secretion levels were enhanced in quercetin-fed normal mice. To elucidate the mechanisms of these effects on salivary secretion, we conducted an analysis using mouse submandibular gland tissues, a human salivary gland epithelial cell line (HSY), and mouse aortic endothelial cells (MAECs). The results showed that quercetin augments aquaporin 5 (AQP5) expression and calcium uptake, and suppresses oxidative stress and inflammatory responses induced by radiation exposure, suggesting that quercetin intake may be an effective method to treat impaired salivary secretion. |
format | Online Article Text |
id | pubmed-4309588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43095882015-02-06 Evaluation of the Effects of Quercetin on Damaged Salivary Secretion Takahashi, Ayako Inoue, Hiroko Mishima, Kenji Ide, Fumio Nakayama, Ryoko Hasaka, Ayaka Ryo, Koufuchi Ito, Yumi Sakurai, Takashi Hasegawa, Yoshinori Saito, Ichiro PLoS One Research Article With the aim of discovering an effective method to treat dry mouth, we analyzed the effects of quercetin on salivary secretion and its mechanism of action. We created a mouse model with impaired salivary secretion by exposure to radiation and found that impaired secretion is suppressed by quercetin intake. Moreover, secretion levels were enhanced in quercetin-fed normal mice. To elucidate the mechanisms of these effects on salivary secretion, we conducted an analysis using mouse submandibular gland tissues, a human salivary gland epithelial cell line (HSY), and mouse aortic endothelial cells (MAECs). The results showed that quercetin augments aquaporin 5 (AQP5) expression and calcium uptake, and suppresses oxidative stress and inflammatory responses induced by radiation exposure, suggesting that quercetin intake may be an effective method to treat impaired salivary secretion. Public Library of Science 2015-01-28 /pmc/articles/PMC4309588/ /pubmed/25629520 http://dx.doi.org/10.1371/journal.pone.0116008 Text en © 2015 Takahashi et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Takahashi, Ayako Inoue, Hiroko Mishima, Kenji Ide, Fumio Nakayama, Ryoko Hasaka, Ayaka Ryo, Koufuchi Ito, Yumi Sakurai, Takashi Hasegawa, Yoshinori Saito, Ichiro Evaluation of the Effects of Quercetin on Damaged Salivary Secretion |
title | Evaluation of the Effects of Quercetin on Damaged Salivary Secretion |
title_full | Evaluation of the Effects of Quercetin on Damaged Salivary Secretion |
title_fullStr | Evaluation of the Effects of Quercetin on Damaged Salivary Secretion |
title_full_unstemmed | Evaluation of the Effects of Quercetin on Damaged Salivary Secretion |
title_short | Evaluation of the Effects of Quercetin on Damaged Salivary Secretion |
title_sort | evaluation of the effects of quercetin on damaged salivary secretion |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309588/ https://www.ncbi.nlm.nih.gov/pubmed/25629520 http://dx.doi.org/10.1371/journal.pone.0116008 |
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