Imputation of the Rare HOXB13 G84E Mutation and Cancer Risk in a Large Population-Based Cohort

An efficient approach to characterizing the disease burden of rare genetic variants is to impute them into large well-phenotyped cohorts with existing genome-wide genotype data using large sequenced referenced panels. The success of this approach hinges on the accuracy of rare variant imputation, wh...

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Detalles Bibliográficos
Autores principales: Hoffmann, Thomas J., Sakoda, Lori C., Shen, Ling, Jorgenson, Eric, Habel, Laurel A., Liu, Jinghua, Kvale, Mark N., Asgari, Maryam M., Banda, Yambazi, Corley, Douglas, Kushi, Lawrence H., Quesenberry, Charles P., Schaefer, Catherine, Van Den Eeden, Stephen K., Risch, Neil, Witte, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309593/
https://www.ncbi.nlm.nih.gov/pubmed/25629170
http://dx.doi.org/10.1371/journal.pgen.1004930

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