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Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response

RNA-sensing toll-like receptors (TLRs) mediate innate immunity and regulate anti-viral response. We show here that TLR3 regulates host immunity and the loss of TLR3 aggravates pathology in Chikungunya virus (CHIKV) infection. Susceptibility to CHIKV infection is markedly increased in human and mouse...

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Detalles Bibliográficos
Autores principales:	Her, Zhisheng, Teng, Terk-Shin, Tan, Jeslin JL, Teo, Teck-Hui, Kam, Yiu-Wing, Lum, Fok-Moon, Lee, Wendy WL, Gabriel, Christelle, Melchiotti, Rossella, Andiappan, Anand K, Lulla, Valeria, Lulla, Aleksei, Win, Mar K, Chow, Angela, Biswas, Subhra K, Leo, Yee-Sin, Lecuit, Marc, Merits, Andres, Rénia, Laurent, Ng, Lisa FP
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309666/ https://www.ncbi.nlm.nih.gov/pubmed/25452586 http://dx.doi.org/10.15252/emmm.201404459

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