REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids

Cutaneous atrophy is the major adverse effect of topical glucocorticoids; however, its molecular mechanisms are poorly understood. Here, we identify stress-inducible mTOR inhibitor REDD1 (regulated in development and DNA damage response 1) as a major molecular target of glucocorticoids, which mediat...

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Detalles Bibliográficos
Autores principales: Baida, Gleb, Bhalla, Pankaj, Kirsanov, Kirill, Lesovaya, Ekaterina, Yakubovskaya, Marianna, Yuen, Kit, Guo, Shuchi, Lavker, Robert M, Readhead, Ben, Dudley, Joel T, Budunova, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309667/
https://www.ncbi.nlm.nih.gov/pubmed/25504525
http://dx.doi.org/10.15252/emmm.201404601

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