Global Deletion of Trp53 Reverts Ovarian Tumor Phenotype of the Germ Cell–Deficient White Spotting Variant (Wv) Mice()

White spotting variant (Wv) mice are spontaneous mutants attributed to a point mutation in the c-Kit gene, which reduces the tyrosine kinase activity to around 1% and affects the development of melanocytes, mast cells, and germ cells. Homozygous mutant mice are sterile but can live nearly a normal l...

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Detalles Bibliográficos
Autores principales: Cai, Kathy Qi, Wang, Ying, Smith, Elizabeth R., Smedberg, Jennifer L., Yang, Dong-Hua, Yang, Wan-Lin, Xu, Xiang-Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309726/
https://www.ncbi.nlm.nih.gov/pubmed/25622902
http://dx.doi.org/10.1016/j.neo.2014.11.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309726/
https://www.ncbi.nlm.nih.gov/pubmed/25622902
http://dx.doi.org/10.1016/j.neo.2014.11.005

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