Suppression of Tumor Growth in Mice by Rationally Designed Pseudopeptide Inhibitors of Fibroblast Activation Protein and Prolyl Oligopeptidase()

Tumor microenvironments (TMEs) are composed of cancer cells, fibroblasts, extracellular matrix, microvessels, and endothelial cells. Two prolyl endopeptidases, fibroblast activation protein (FAP) and prolyl oligopeptidase (POP), are commonly overexpressed by epithelial-derived malignancies, with the...

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Detalles Bibliográficos
Autores principales: Jackson, Kenneth W., Christiansen, Victoria J., Yadav, Vivek R., Silasi-Mansat, Robert, Lupu, Florea, Awasthi, Vibhudutta, Zhang, Roy R., McKee, Patrick A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309729/
https://www.ncbi.nlm.nih.gov/pubmed/25622898
http://dx.doi.org/10.1016/j.neo.2014.11.002

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