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Multifunction hexagonal liquid-crystal containing modified surface TiO(2) nanoparticles and terpinen-4-ol for controlled release

Multifunctional products have been developed to combine the benefits of functional components and terpinen-4-ol (TP) delivery systems. In this way, p-toluene sulfonic acid modified titanium dioxide (TiO(2)) nanoparticles and TP, an antioxidant, have been incorporated in liquid-crystalline formulatio...

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Autores principales: Manaia, Eloísa Berbel, Kaminski, Renata Cristina Kiatkoski, de Oliveira, Anselmo Gomes, Corrêa, Marcos Antonio, Chiavacci, Leila Aparecida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309795/
https://www.ncbi.nlm.nih.gov/pubmed/25653523
http://dx.doi.org/10.2147/IJN.S71980
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author Manaia, Eloísa Berbel
Kaminski, Renata Cristina Kiatkoski
de Oliveira, Anselmo Gomes
Corrêa, Marcos Antonio
Chiavacci, Leila Aparecida
author_facet Manaia, Eloísa Berbel
Kaminski, Renata Cristina Kiatkoski
de Oliveira, Anselmo Gomes
Corrêa, Marcos Antonio
Chiavacci, Leila Aparecida
author_sort Manaia, Eloísa Berbel
collection PubMed
description Multifunctional products have been developed to combine the benefits of functional components and terpinen-4-ol (TP) delivery systems. In this way, p-toluene sulfonic acid modified titanium dioxide (TiO(2)) nanoparticles and TP, an antioxidant, have been incorporated in liquid-crystalline formulations for photoprotection and controlled release of the TP, respectively. By X-ray powder diffraction and diffuse reflectance spectroscopy, we noted that using p-toluene sulfonic acid as a surface modifier made it possible to obtain smaller and more transparent TiO(2) nanoparticles than those commercially available. The liquid-crystalline formulation containing the inorganic ultraviolet filter was classified as broad-spectrum performance by the absorbance spectroscopy measurements. The formulations containing modified TiO(2) nanoparticles and TP were determined to be in the hexagonal phase by polarized light microscopy and small-angle X-ray scattering, which makes possible the controlled released of TP following zero-order kinetics. The developed formulations can control the release of TP. Constant concentrations of the substance have been released per time unit, and the modified TiO(2) nanoparticles can act as a transparent inorganic sunscreen.
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spelling pubmed-43097952015-02-04 Multifunction hexagonal liquid-crystal containing modified surface TiO(2) nanoparticles and terpinen-4-ol for controlled release Manaia, Eloísa Berbel Kaminski, Renata Cristina Kiatkoski de Oliveira, Anselmo Gomes Corrêa, Marcos Antonio Chiavacci, Leila Aparecida Int J Nanomedicine Original Research Multifunctional products have been developed to combine the benefits of functional components and terpinen-4-ol (TP) delivery systems. In this way, p-toluene sulfonic acid modified titanium dioxide (TiO(2)) nanoparticles and TP, an antioxidant, have been incorporated in liquid-crystalline formulations for photoprotection and controlled release of the TP, respectively. By X-ray powder diffraction and diffuse reflectance spectroscopy, we noted that using p-toluene sulfonic acid as a surface modifier made it possible to obtain smaller and more transparent TiO(2) nanoparticles than those commercially available. The liquid-crystalline formulation containing the inorganic ultraviolet filter was classified as broad-spectrum performance by the absorbance spectroscopy measurements. The formulations containing modified TiO(2) nanoparticles and TP were determined to be in the hexagonal phase by polarized light microscopy and small-angle X-ray scattering, which makes possible the controlled released of TP following zero-order kinetics. The developed formulations can control the release of TP. Constant concentrations of the substance have been released per time unit, and the modified TiO(2) nanoparticles can act as a transparent inorganic sunscreen. Dove Medical Press 2015-01-22 /pmc/articles/PMC4309795/ /pubmed/25653523 http://dx.doi.org/10.2147/IJN.S71980 Text en © 2015 Manaia et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Manaia, Eloísa Berbel
Kaminski, Renata Cristina Kiatkoski
de Oliveira, Anselmo Gomes
Corrêa, Marcos Antonio
Chiavacci, Leila Aparecida
Multifunction hexagonal liquid-crystal containing modified surface TiO(2) nanoparticles and terpinen-4-ol for controlled release
title Multifunction hexagonal liquid-crystal containing modified surface TiO(2) nanoparticles and terpinen-4-ol for controlled release
title_full Multifunction hexagonal liquid-crystal containing modified surface TiO(2) nanoparticles and terpinen-4-ol for controlled release
title_fullStr Multifunction hexagonal liquid-crystal containing modified surface TiO(2) nanoparticles and terpinen-4-ol for controlled release
title_full_unstemmed Multifunction hexagonal liquid-crystal containing modified surface TiO(2) nanoparticles and terpinen-4-ol for controlled release
title_short Multifunction hexagonal liquid-crystal containing modified surface TiO(2) nanoparticles and terpinen-4-ol for controlled release
title_sort multifunction hexagonal liquid-crystal containing modified surface tio(2) nanoparticles and terpinen-4-ol for controlled release
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309795/
https://www.ncbi.nlm.nih.gov/pubmed/25653523
http://dx.doi.org/10.2147/IJN.S71980
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